苦参汤加减联合四物消风散对肛门瘙痒症患者肛周皮损、瘙痒症状及复发率的影响  

The Influence of Modified Light Yellow Sophora Root Decoction Combined with Four-Medicinal Wind-Dispersing Decoction on Perianal Skin Lesions and Pruritus Symptoms and Recurrence Rate in Patients with Pruritus Ani

作　　者：刘翠杨 刘小毅 史格格 孙赫宇 LIU Cuiyang;LIU Xiaoyi;SHI Gege;SUN Heyu(Luoyang Dongfang People's Hospital,Luoyang,Henan,China,471000;Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou,Henan,China,450000)

机构地区：[1]洛阳市东方人民医院,河南洛阳471000 [2]河南省中医院,河南郑州450000

出　　处：《河南中医》2024年第9期1413-1417,共5页Henan Traditional Chinese Medicine

基　　金：河南省卫生健康委员会科技攻关项目(LHGJ20190623)。

摘　　要：目的:观察苦参汤加减联合四物消风散对肛门瘙痒症患者肛周皮损、瘙痒症状及复发率的影响。方法:选取2020年9月至2022年6月治疗的血虚生风型肛门瘙痒症患者98例,采用随机数字表法分为联合组和对照组,各49例。对照组采用左西替利嗪片治疗,联合组在对照组治疗的基础上加用苦参汤加减坐浴联合四物消风散内服治疗。观察两组患者治疗前后中医证候积分、症状评分、血清炎性因子水平[干扰素-γ(interferon-γ,IFN-γ)、白细胞介素(interleukin,IL)-4及IL-18]变化情况及临床疗效、复发率、不良反应发生情况。结果:联合组治疗后中医证候积分低于对照组,差异有统计学意义(P<0.05);联合组治疗后瘙痒程度、皮损状况、潮湿等症状评分低于对照组,差异有统计学意义(P<0.05);联合组治疗后IFN-γ、IL-4、IL-18水平均低于对照组,差异具有统计学意义(P<0.05);联合组有效率为97.96%,对照组有效率为85.71%,联合组有效率高于对照组,差异具有统计学意义(P<0.05);联合组治疗后1个月、3个月复发率均低于对照组,差异具有统计学意义(P<0.05);两组患者治疗过程中均未见明显不良反应发生。结论:苦参汤加减坐浴联合四物消风散内服治疗肛门瘙痒症可以减轻患者肛周皮损、瘙痒、潮湿等症状,提高临床疗效,降低血清炎性因子水平及复发率。Objective:To observe the influence of Modified Light Yellow Sophora Root Decoction combined with Four-Medicinal Wind-Dispersing Decoction on perianal skin lesions and pruritus symptoms and the recurrence rate in patients with pruritus ani(PA).Methods:A total of 98 patients with PA of blood deficiency type treated from September 2020 to June 2022 were selected and divided into the combined group and the control group according to random number table method,with 49 cases in each group.The control group was treated with Levocetirizine Tablets,while the combined group was treated with Modified Light Yellow Sophora Root Decoction for sitz bath combined with Four-Medicinal Wind-Dispersing Decoction for oral administration.The changes in the patients′ TCM syndrome scores,symptom score,serum inflammatory factor levels [interferon-γ(IFN-γ),interleukin(IL)-4 and IL-18] before and after treatment,clinical efficacy,recurrence rate,and adverse reaction incidence were observed in the two groups.Results:After treatment,the TCM syndrome scores in the combined group were lower than those in the control group,and the differences were statistically significant(P<0.05);The score of itching degree,skin lesion condition,dampness and other symptoms in the combined group were lower than those in the control group,and the differences were statistically significant(P<0.05);the levels of IFN-γ,IL-4 and IL-18 in the combined group were lower than those of the control group,and the differences were statistically significant(P<0.05);the effective rate of the combined group was 97.96%,while that of the control group was 85.71%,the effective rate of the combination group was higher than that of the control group,and the difference was statistically significant(P<0.05);the recurrence rates of the combined group at the 1st and 3rd month were lower than those of the control group,and the differences were statistically significant(P<0.05);no significant adverse reactions were observed during the treatment of both groups.Conclusion:Modified Lig

关 键 词：肛门瘙痒症 苦参汤 四物消风散 肛周皮损 瘙痒 复发率 

分 类 号：R266[医药卫生—中医外科学]