奥沙西泮精制方法的研究  

Study on Refining Method of Oxazepam

作　　者：罗浩 廖俊[1] LUO Hao;LIAO Jun(Huazhong Pharmaceutical Co.,Ltd.,Xiangyang 441021,China)

机构地区：[1]华中药业股份有限公司,湖北襄阳441021

出　　处：《化工技术与开发》2024年第9期83-85,89,共4页Technology & Development of Chemical Industry

摘　　要：本文研究了奥沙西泮的精制方法。用酰胺类偶极亲质子溶剂溶解奥沙西泮粗品,经过滤、加水水析、过滤、在酮类溶剂中打浆等操作,得到了高纯度的奥沙西泮。该方法可有效降低奥沙西泮的杂质Ⅱ(6-氯-4-苯基喹啉-2-甲醛)的含量,大幅减少精制溶剂的用量,成本低,收率高,适合工业化生产。The refining method of oxazepam was studied in this paper.The crude oxazepam was dissolved in amide dipolar protophilic solvent,then through filtered,water eluted,filtered,and beaten in ketone solvent,the high purity oxazepam was obtained.The method effectively reduced the content of oxazepam impurity Ⅱ(6-chloro-4-phenylquinoline-2-formaldehyde),greatly reduced the amount of refining solvent,had low cost and high yield,and was suitable for industrial production.

关 键 词：奥沙西泮 6-氯-4-苯基喹啉-2-甲醛 制备 精制 

分 类 号：TQ460.64[化学工程—制药化工]