儿童重症博卡病毒感染的临床特点分析  

Analysis of clinical characteristics of severe human bocavirus infection in children

作　　者：吴立都 武宇辉 张楠[1] WU Lidu;WU Yuhui;ZHANG Nan(Department of Pediatric Intensive Care Unit,Shenzhen Children’s Hospital Affiliated to Shantou Medical University,Guangdong Province,Shenzhen 518038,China)

机构地区：[1]汕头大学深圳市儿童医院儿童重症医学科,广东深圳518038

出　　处：《妇儿健康导刊》2024年第17期183-188,共6页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：广东省深圳市“医疗卫生三名工程”项目资助(SZSM202211034)。

摘　　要：目的 分析儿童重症博卡病毒(HBo V)感染的临床特点。方法 回顾性分析2019年11月至2023年12月汕头大学深圳市儿童医院儿童重症监护病房(PICU)收治的76例HBoV检测阳性患儿的临床资料。结果 纳入的患儿中,有72例符合重症肺炎诊断,男49例,女23例,年龄19.4(3.0,96.0)个月;10~12月发病37例(51.4%);PICU住院时间为5.1(1.0,31.0)d;合并急性呼吸衰竭48例(66.7%);气管插管机械通气28例(38.9%);单纯HBoV感染29例(40.3%),混合感染43例(59.7%);单纯HBoV感染组与混合感染组PICU住院时间、并发症发生率、使用机械通气率比较,差异无统计学意义(P>0.05);相较于单纯HBoV感染组,混合感染组总住院时间更长(P <0.05)。≤1岁组和> 1岁组的总住院时间、PICU住院时间、并发症发生率、使用机械通气率比较,差异无统计学意义(P>0.05)。基础疾病组总住院时间、PICU住院时间均长于无基础疾病组,差异有统计学意义(P <0.05)。结论 HBoV可作为单独致病病原引起重症肺炎,患儿以呼吸衰竭为主要并发症。合并基础疾病、存在混合感染的患儿需要较长时间的重症监护治疗,临床须予以重视。Objective To analyze the clinical characteristics of severe human bocavirus(HBoV)infection in children.Methods A retrospective analysis was conducted on the clinical data of children tested positive for HBoV in Pediatric Intensive Care Unit(PICU),Shenzhen Children’s Hospital Affiliated to Shantou Medical University from November 2019 to December 2023.Results Among the included children,72 were diagnosed with severe pneumonia,including 49 males and 23 females,aged 19.4(3.0,96.0)months.37 cases(51.4%)occurred from October to December.The length of hospitalization for PICU was 5.1(1.0,31.0)days.There were 48 cases(66.7%)with acute respiratory failure.28 cases(38.9%)were intubated with mechanical ventilation.There were 29 cases(40.3%)with simple HBoV infection and 43 cases(59.7%)with mixed infection.There were no significant differences in PICU stay time,complication rate and mechanical ventilation rate between simple HBoV infection group and mixed infection group(P>0.05).The total hospitalization time in the mixed infection group was longer than that in the simple HBoV infection group(P<0.05).There were no significant differences in total hospitalization time,PICU stay time,complication rate and mechanical ventilation rate between≤1 year old group and>1 year old group(P>0.05).The total hospitalization time and PICU stay time in the basic disease group were longer than those in the no basic disease group,the differences were statistically significant(P<0.05).Conclusion HBoV can cause severe pneumonia as a single pathogen,and respiratory failure is the main complication in children.Children with basic diseases and mixed infections need a longer period of intensive care treatment,which should be paid attention in clinical practice.

关 键 词：儿童 博卡病毒 重症肺炎 临床特点 

分 类 号：R725.6[医药卫生—儿科]