西维来司他钠联合血必净治疗对重症肺炎患者血气分析指标及血清APC、4-HNE水平的影响  

Effects of cilvelestat sodium combined with Xuebijing on blood gas analysis indexes and serum APC and 4-HNE levels in patients with severe pneumonia

作　　者：周岩 谢中兰 丁晓芳 王志信 ZHOU Yan;XIE Zhonglan;DING Xiaofang;WANG Zhixin(Shangqiu Central Hospital,Department of Respiratory and Critical Care Medicine,Shangqiu 476000,China;Shangqiu Central Hospital,Department of Critical Care Medicine,Shangqiu 476000,China)

机构地区：[1]商丘市中心医院呼吸与危重症医学科,河南商丘476000 [2]商丘市中心医院重症医学科,河南商丘476000

出　　处：《黑龙江医药科学》2024年第5期72-75,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关联合共建项目,编号:LHGJ20222144。

摘　　要：目的:探究西维来司他钠联合血必净治疗重症肺炎对血气分析、血清炎性因子的影响。方法:回顾性选取商丘市中心医院2021年6月至2023年6月收治的60例重症肺炎患者病历资料,根据治疗方案不同分为两组,各30例。两组均给予常规治疗,基于此参照组给予西维来司他钠治疗,联合组予以血必净+西维来司他钠治疗。对比两组肺功能[呼气流量峰值(PEF)、第1秒用力呼气末容积(FEV1)、FEV1/用力肺活量(FVC)]、血气分析指标[动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(OI)]、炎性因子水平[4羟基壬烯醛(4-HNE)、活化蛋白(APC)、C反应蛋白(CRP)]、T细胞亚群[CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)]、用药安全性。结果:治疗7 d、14 d后,联合组FEV1、PEF、FEV1/FVC、PaO_(2)、OI高于参照组,PaCO_(2)低于参照组(P<0.05);治疗7 d、14 d后,联合组APC、CD4^(+)、CD4^(+)/CD8^(+)、CD3^(+)高于参照组,4-HNE、CRP低于参照组(P<0.05)。结论:西维来司他钠联合血必净治疗重症肺炎可改善肺功能、血气分析指标,调节T细胞亚群,抑制炎性反应,利于病情转归,安全性较高。Objective:To explore the effects of cilvelestat sodium combined with Xuebijing on blood gas analysis and serum inflammatory factors in the treatment of severe pneumonia.Methods:A total of 60 cases of severe pneumonia admitted to Shangqiu Central Hospital from June 2021 to June 2023 were retrospectively selected and divided into two groups with 30 cases each according to different treatment plans.Both groups were given conventional treatment,based on which the reference group was given cilvelestat sodium and the combination group was given serbiazine plus cilvelestat sodium.Pulmonary function[peak expiratory flow(PEF),forced end-expiratory volume in the first second(FEV1),FEV1/forced vital capacity(FVC)],blood gas analysis indexes[partial pressure of arterial oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2)),oxygenation index(OI)],inflammatory factor level[4-hydroxynonenal(4-HNE),and activated protein(APC),C-reactive protein(CRP)],T cell subsets[CD4^(+),CD3^(+),CD4^(+)/CD8^(+)],drug safety were compared between the two groups.Results:After 7 and 14 days of treatment,FEV1,PEF,FEV1/FVC,PaO_(2) and OI in combination group were higher than those in reference group,and PaCO_(2) was lower than those in reference group(P<0.05).After 7 and 14 days of treatment,APC,CD4^(+),CD4^(+)/CD8^(+),CD3^(+)in combination group were higher than those in reference group,and 4-HNE and CRP were lower than those in reference group(P<0.05).Conclusion:Cilvelestat sodium combined with Xuebijing in the treatment of severe pneumonia can improve lung function,blood gas analysis index,regulate T cell subsets,inhibit inflammatory response,and is beneficial to the outcome of the disease with high safety.

关 键 词：西维来司他钠 血必净 重症肺炎 活化蛋白 血气分析 

分 类 号：R563.8[医药卫生—呼吸系统]