依折麦布、阿托伐他汀联合治疗对颈动脉粥样硬化患者T细胞分化亚群及6-keto-PGF1α、TXB2的影响  

Effect of combined treatment with ezetimibe and atorvastatinon T cell differentiation subsets, 6-keto-PGF1α and TXB2in patients with carotid atherosclerosis

作　　者：蔺建云 周梦 苏钰 LIN Jianyun;ZHOU Meng;SU Yu(Department of Pharmacy,Anyang People's Hospital,Anyang 455000,China)

机构地区：[1]安阳市人民医院药学部,河南安阳455000

出　　处：《黑龙江医药科学》2024年第5期169-172,共4页Heilongjiang Medicine and Pharmacy

摘　　要：目的:回顾性探讨依折麦布与阿托伐他汀联合治疗颈动脉粥样硬化(CAS)对患者T细胞分化亚群、血管内皮功能、颈动脉内膜-中层厚度(IMT)的影响。方法:选取安阳市人民医院2021年1月至2023年6月收治的CAS患者病历资料,根据不同治疗方案将100例患者分为两组,各50例。对照组予以阿托伐他汀治疗,联合组予以依折麦布+阿托伐他汀治疗。治疗3个月后,对比两组IMT、斑块面积、血管内皮功能[非内皮依赖性功能(NMD)、肱动脉内皮依赖性功能(FMD)]、血脂水平[高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)]、T细胞分化亚群比例[辅助T细胞(Th)1、Th2、Th17、调节性T细胞(Treg)]、6-酮-前列腺素1α(6-keto-PGF1α)、一氧化氮(NO)、血栓素B2(TXB2)、内皮素(ET)水平及不良反应。结果:治疗后,联合组IMT、斑块面积小于对照组,IMT、斑块面积大于对照组(P<0.05);治疗后,联合组HDL-C、6-keto-PGF1α、NO高于对照组,TC、LDL-C、TG、ET、TXB2低于对照组(P<0.05);治疗后,联合组Th1、Th2、Th17比例低于对照组,Treg比例高于对照组(P<0.05);不良反应发生率两组差异无统计学意义(P>0.05)。结论:依折麦布与阿托伐他汀联合治疗CAS可有效控制血脂水平,减轻机体炎症,改善血管内皮功能,减小IMT、斑块面积,控制病情进展,安全性较高。Objective:To review the effects of ezetimibe combined with atorvastatin on T cell differentiation,vascular endothelial function and carotid intima-media thickness(C-IMT)in patients with carotid atherosclerosis(CAS).Methods:Medical records of CAS patients admitted to our hospital from January 2021 to June 2023 were collected,and 100 patients were divided into two groups with 50 cases each according to different treatment regiments.The control group was given atorvastatin,and the combination group was given ezetimibe+atorvastatin.Three months after treatment,The C-IMT,plaque area,vascular endothelial function[NMD,FMD],lipid level[high density lipoprotein cholesterol(HDL-C),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceride(TG)],Proportion of T cell differentiation subsets[helper T cells(Th)1,Th2,Th17,regulatory T cells(Treg)],6-keto-prostagstagin 1α(6-keto-PGF1α),nitric oxide(NO),thromboxane B2(TXB2),endothelin(ET)levels and adverse reactions between the two groups were compared.Results:After treatment,C-IMT and plaque area in combination group were lower than control group,and C-IMT and plaque area were higher than control group(P<0.05).After treatment,HDL-C,6-keto-PGF1αand NO in combination group were higher than those in control group,TC,LDL-C,TG,ET and TXB2 were lower than those in control group(P<0.05).After treatment,the proportion of Th1,Th2 and Th17 in combination group was lower than that in control group,and the proportion of Treg was higher than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of ezetimibe and atorvastatin in the treatment of CAS can effectively control blood lipid levels,reduce inflammation,improve vascular endothelial function,reduce C-IMT and plaque area,and control disease progression,with high safety.

关 键 词：依折麦布 阿托伐他汀 颈动脉粥样硬化 血管内皮功能 T细胞分化亚群 

分 类 号：R543.5[医药卫生—心血管疾病]