补铁治疗在心血管疾病中的作用机制和潜在获益研究进展  

Research progress on the mechanism and potential beneffts of iron supplementation in cardiovascular diseases

作　　者：滕苗苗 伍锋 樊民[1] TENG Miaomiao;WU Feng;FAN Min(Department of Cardiology,Yueyang Hospital of Integrated Traditional Chinese and Werstern Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院心内科,上海200437

出　　处：《世界临床药物》2024年第8期891-896,共6页World Clinical Drug

基　　金：上海市卫健委项目(20214Y0179)。

摘　　要：铁缺乏影响着全球约三分之一的人口,在老年人、女性以及某些慢性疾病患者中尤为多见。铁缺乏对于冠状动脉疾病、心力衰竭(heart failure,HF)、肺动脉高压(pulmonary arterial hypertension,PAH)以及接受心脏手术的患者均有着不利影响,约50%的HF患者和PAH患者合并铁缺乏。抗血栓药物的广泛使用会增加出血风险,进而导致出血相关缺铁性贫血的发生率增高。近期研究表明,补充铁剂可显著改善射血分数降低HF患者生活质量及再入院率。但其在各类心血管疾病中的作用机制尚不明确。该文将从补铁治疗在各类心血管疾病中获益的证据出发,对其在各类心血管疾病中的作用机制及潜在获益作综述。Iron deffciency affects about a third of the global population and is particularly common in the elderly,women and those with certain chronic conditions.Iron deffciency has adverse effects on coronary artery disease,heart failure,pulmonary hypertension,and patients undergoing cardiac surgery,with approximately 50%of patients with heart failure and pulmonary hypertension having iron deffciency.The widespread use of antithrombotic drugs increases the risk of bleeding,which in turn increases the incidence of hemorrhage-related iron deffciency anemia.Recent studies have shown that iron supplementation can signiffcantly improve quality of life and readmission rates in heart failure patients with reduced ejection fraction.However,the mechanism of its action in various cardiovascular diseases is still unclear.Based on the evidence of the beneffts of iron supplementation in various cardiovascular diseases,this article reviewed the mechanism and potential beneffts of iron supplementation in various cardiovascular diseases.

关 键 词：补铁治疗 心血管疾病 心力衰竭 

分 类 号：R977.5[医药卫生—药品] R54[医药卫生—药学]