谷氨酰转肽酶的变化趋势与代谢综合征患病风险关系的社区队列研究  

The relationship between the trend of glutamyl transpeptidase changes and the risk of metabolic syndrome:a community cohort study

作　　者：曲建昌 窦京涛[2] 王安平[2] 谷伟军[2] 吕朝晖[2] 母义明[2] QU Jianchang;DOU Jingtao;WANG Anping(Department of Endocrinology,The 305 Hospital of PLA,Beijing 100017,China;不详)

机构地区：[1]解放军第三〇五医院内分泌科,北京100017 [2]解放军总医院第一医学中心内分泌科

出　　处：《中国糖尿病杂志》2024年第8期581-586,共6页Chinese Journal of Diabetes

基　　金：解放军第三〇五医院院内基金重点项目(21YNZD01)。

摘　　要：目的采用社区队列研究探讨谷氨酰转肽酶(GGT)的变化与新发MS患病风险的相关性。方法本研究为前瞻性队列研究,基线数据来源为“REACTION”研究的北京分中心人群,纳入6482名非MS研究对象,参照GGT水平以四分位法分为G1组(GGT<14.2 U/L,n=1613)、G2组(14.2≤GGT<18.6 U/L,n=1602)、G3组(18.6≤GGT<26.1 U/L,n=1639)及G4组(GGT≥26.1 U/L,n=1628)。于3.2年后进行随访,分析基线GGT及GGT变化趋势与新发MS风险的关系。结果基线GGT是新发MS的危险因素,与G1组比较,G2、G3、G4组随访时新发MS的相对危险度(RR)(95%CI)为1.480(1.220~1.780,P<0.01)、2.090(1.750~2.490,P<0.01)及2.800(2.360~3.320,P<0.01)。GGT升高是新发MS的危险因素,与GGT下降组比较,GGT上升组随访时新发MS的RR(95%CI)为1.410(1.320~1.510,P<0.01)。分层亚组分析显示,在女性及中年人群中,GGT上升组较GGT下降组,新发MS的RR(95%CI)升高1.650[(1.410~1.940)vs 1.510(1.310~1.750),P<0.01]。在男性和老年人群中,高GGT上升组与GGT下降组比较,新发MS的风险差异无统计学意义(P>0.05)。结论GGT上升是新发MS的危险因素,在女性及中年人群中更明显。Objective To evaluate the relationship between the trend of glutamyl transpeptidase(GGT)change and newly developed metabolic syndrome(MS),and to explore the relationship between GGT and MS.Methods The study was a prospective cohort study,with baseline data sourced from the Beijing subcenter population of the“REACTION”study.A total of 6482 non-MS subjects was enrolled as the study subjects,and divided into four groups using the quartile method based on GGT level:G1(GGT<14.2 U/L,n=1613),G2(14.2≤GGT<18.6 U/L,n=1602),G3(18.6≤GGT<26.1 U/L,n=1639)and G4(GGT≥26.1 U/L,n=1628)group.Follow up was conducted 3.2 years later to analyze the correlation between baseline GGT and the trend of GGT changes with the risk of new MS.Results Baseline GGT was a risk factor for newly diagnosed MS.Compared with G1 group,the relative risk(RR)(95%CI)of newly diagnosed MS at follow-up in G2,G3,G4 group were 1.480(1.220~1.780,P<0.01),2.090(1.750~2.490,P<0.01),and 2.800(2.360~3.320,P<0.01),respectively.The increase in GGT is a risk factor for newly diagnosed MS during follow-up in this population.Compared with the group with decreased GGT,the RR(95%CI)of newly diagnosed MS during follow-up was 1.410(1.320~1.510)(P<0.01)in the group with increased GGT.In stratified subgroup analysis,the incidence of new-onset MS was[1.650(1.410~1.940)vs 1.510(1.310~1.750),P<0.01]respectively in female and middle-aged people in the GGT increase group compared with the GGT decrease group.There was no statistically significant difference in the risk of developing new MS in both male and elderly populations between the GGT increasing group and the decreasing group(P>0.05).Conclusions The increase in GGT is a risk factor for newly diagnosed MS,especially in female and middle-aged populations.

关 键 词：谷氨酰转肽酶 代谢综合征 危险因素 变化趋势 

分 类 号：R589[医药卫生—内分泌]