空间微重力环境下脑内神经化学物质响应的研究进展  

Research progress on neurochemical responses within the brain under microgravity

作　　者：侯莉娟[1] 张永祺 杨昕 陈善广[2] 毛兰群 HOU Li-Juan;ZHANG Yong-Qi;YANG Xin;CHEN Shan-Guang;MAO Lan-Qun(College of P.E.and Sports,Beijing Normal University,Beijing 100875,China;National Key Laboratory of Human Factors Engineering,China Astronaut Research and Training Center,Beijing 100094,China;College of Chemistry,Beijing Normal University,Beijing 100875,China)

机构地区：[1]北京师范大学体育与运动学院,北京100875 [2]中国航天员科研训练中心人因工程全国重点实验室,北京100094 [3]北京师范大学化学学院,北京100875

出　　处：《生命科学》2024年第8期991-999,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(22134002,T2192933)。

摘　　要：2023年我国天宫空间站建设完成,空间站为探索宇宙及开展航天科学实验搭建了平台。大脑作为高级认知功能的调控中枢,在空间微重力等特殊环境下产生适应性变化保障航天员长时间太空任务的执行,而脑内神经化学递质是大脑稳态重塑中的关键调节物质,因此解析微重力环境下脑内神经化学物质的响应特征,能够为航天员健康及后续载人登月、深空探测等任务顺利实施提供理论参考。本文综述了空间环境下脑机制研究的动物实验平台现状,以及脑内主要神经化学物质失重响应的相关研究,并分析了活体脑神经化学分析方法的新原理及应用,为未来我国空间站开展脑科学领域神经化学活体研究和相关技术平台的搭建提供参考。In 2023,China Tiangong space station was completed.It supplies an experiment platform for improving scientific understanding of the universe and carrying out the space research.The brain,as the regulatory center involved in cognitive function,was found to pursue adaptive changes in the special space environments to make sure of the astronauts’task finishing.Neurochemicals in the brain play a key regulatory role in the homeostasis,so understanding their changes can supply theoretical support for astronaut health during future manned lunar landing and deep space exploration.This paper reviewed experiment platforms for animal research in space station,the response of neurochemicals in the brain,and analyzed the original theory of in vivo electrochemistry technique and its future application,aiming to provide references for space brain science researching and new ideas for setting up neurochemical technical platforms in China Space Station.

关 键 词：空间微重力 神经化学 大脑 多巴胺 活体原位电化学 

分 类 号：Q426[生物学—神经生物学] R854[生物学—生理学]