持续与间歇蓝光照射治疗高胆红素血症新生儿的临床疗效  

Clinical Efficacy of Continuous and Intermittent Blue Light Irradiation in the Treatment of Neonates with Hyperbilirubinemia

作　　者：段春蓉 DUAN Chun-rong(Department of Pediatrics,Nanfeng County People's Hospital,Nanfeng 344500,Jiangxi,China)

机构地区：[1]南丰县人民医院儿科,江西南丰344500

出　　处：《医学信息》2024年第18期116-119,共4页Journal of Medical Information

摘　　要：目的观察持续与间歇蓝光照射治疗高胆红素血症新生儿的临床疗效。方法选取2021年8月-2023年8月我院诊治的62例高胆红素血症新生儿为研究对象,采用随机数字表法分为对照组和观察组,各组31例。对照组采用持续蓝光照射治疗,观察组采用间歇蓝光照射治疗,比较两组临床疗效、不同时间黄疸指数、胆红素水平、免疫功能指标、不良反应发生率。结果观察组治疗总有效率为93.55%,高于对照组的80.65%(P<0.05);两组治疗第1、3天黄疸指数均低于治疗前,且观察组黄疸指数低于对照组(P<0.05);两组治疗后胆红素水平均低于治疗前(P<0.05),但观察组与对照组胆红素水平比较,差异无统计学意义(P>0.05);两组治疗后外周血CD3+、CD4+水平均高于治疗前,且观察组外周血CD3+、CD4+水平均高于对照组(P<0.05);观察组不良反应发生率为9.68%,低于对照组的19.35%(P<0.05)。结论与持续蓝光照射治疗相比,间歇蓝光照射治疗可提升高胆红素血症新生儿的临床疗效,降低胆红素水平、黄疸指数,改善免疫功能指标,且可降低不良反应发生率,具有重要的临床应用价值。Objective To observe the clinical efficacy of continuous and intermittent blue light irradiation in the treatment of neonates with hyperbilirubinemia.Methods A total of 62 neonates with hyperbilirubinemia diagnosed and treated in our hospital from August 2021 to August 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 31 neonates in each group.The control group was treated with continuous blue light irradiation,and the observation group was treated with intermittent blue light irradiation.The clinical efficacy,jaundice index at different times,bilirubin level,immune function index and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.55%,which was higher than 80.65%in the control group(P<0.05).The jaundice indexe of the two groups on the 1st and 3rd day of treatment were lower than those before treatment,and the jaundice indexes of the observation group was lower than that of the control group(P<0.05).After treatment,the bilirubin levels of the two groups were lower than those before treatment(P<0.05),but there was no significant difference in bilirubin levels between the observation group and the control group(P>0.05).The levels of CD3+and CD4+in peripheral blood of the two groups after treatment were higher than those before treatment,and the levels of CD3+and CD4+in peripheral blood of the observation group were higher than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was 9.68%,which was lower than 19.35%in the control group(P<0.05).Conclusion Compared with continuous blue light irradiation,intermittent blue light irradiation can improve the clinical efficacy of neonates with hyperbilirubinemia,reduce bilirubin level and jaundice index,improve immune function indexes,and reduce the incidence of adverse reactions,which has important clinical application value.

关 键 词：持续蓝光照射 间歇蓝光照射 高胆红素血症 新生儿 

分 类 号：R722.17[医药卫生—儿科]