不同TyG水平糖尿病患者血糖波动、维生素D水平、铁代谢失衡特征及其与糖尿病并发症的相关性分析  

Characteristics of blood glucose fluctuation,vitamin D level and iron metabolism imbalance in diabetic patients with different TyG levels and their correlation with diabetic complications

作　　者：贾文丽[1] 李海峰[2] 金荣荣 JIA Wen-li;LI Hai-feng;JIN Rong-rong(Department of Endocrinology,Bayannur Hospital,Bayannur Inner Mongolia 015000,China;Department of Health Management,Bayannur Hospital,Bayannur Inner Mongolia 015000,China)

机构地区：[1]巴彦淖尔市医院内分泌科,内蒙古巴彦淖尔015000 [2]巴彦淖尔市医院健康管理科,内蒙古巴彦淖尔015000

出　　处：《临床和实验医学杂志》2024年第16期1689-1693,共5页Journal of Clinical and Experimental Medicine

基　　金：内蒙古自治区医学继续教育项目(编号:2020060306064)。

摘　　要：目的探讨不同甘油三酯血糖(TyG)水平糖尿病患者血糖波动、维生素D水平、铁代谢失衡特征及其与糖尿病并发症的相关性。方法回顾性选择2019年1月至2023年12月来巴彦淖尔市医院诊治的2型糖尿病患者240例,根据TyG四分位水平分为Q1组:6.41≤TyG<8.45(n=58),Q2组:8.45≤TyG<8.80(n=61),Q3组:8.80≤TyG<9.41(n=64),Q4组:9.41≤TyG<10.43(n=57)4组;根据患者是否合并慢性并发症,将患者分为合并组(n=155)与未合并组(n=85)。收集所有患者的基本资料(性别、病程、身高、腰围、体重、臀围、计算体重指数、年龄、静息状态下的舒张压/收缩压、腰臀比),检测实验室指标[空腹血糖、糖化血红蛋白、高密度脂蛋白、总胆固醇、甘油三酯、低密度脂蛋白、丙氨转氨酶(ALT)、天冬氨酸转移酶(AST)、尿酸、肌酐、尿素氮、维生素D、铁蛋白、餐后2 h血糖]。对比不同TyG水平糖尿病患者的基本资料、实验室指标水平,分析TyG与有统计学意义指标的相关性,使用单因素分析糖尿病并发症的影响因素,使用Logistic多因素回归分析糖尿病并发症的影响因素,使用ROC曲线分析TyG、维生素D、铁蛋白及三者联合对糖尿病并发症的预测价值。结果Q1、Q2、Q3、Q4组中的高密度脂蛋白、维生素D水平逐渐降低,而空腹血糖、病程、甘油三酯、餐后2 h血糖、体重指数、低密度脂蛋白、尿酸、腰臀比、糖化血红蛋白、肌酐、总胆固醇、铁蛋白逐渐升高,4组组间比较,差异均有统计学意义(P<0.05)。TyG与病程、体重指数、腰臀比、空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白、尿酸、肌酐、铁蛋白均呈正相关(P<0.05),与高密度脂蛋白、维生素D均呈负相关(P<0.05)。单因素分析,合并组的糖化血红蛋白、TyG、低密度脂蛋白、病程、尿酸、体重指数、空腹血糖、肌酐、餐后2 h血糖、总胆固醇、腰臀比、甘油�Ojbective To investigate the characteristics of blood glucose fluctuation,vitamin D level and iron metabolism imbalance in diabetic patients with different triglyceride glucose index(TyG)levels and their correlation with diabetic complications.Methods A total of 240 patients with type 2 diabetes diagnosed and treated in Bayannur Hospital from January 2019 to December 2023 were retrospectively selected.And they were divideed into four groups according to the TyG quartile level:Q1 group:6.41≤TyG<8.45(n=58),Q2 group:8.45≤TyG<8.80(n=61),Q3 group:8.80≤TyG<9.41(n=64),Q4 group:9.41≤TyG<10.43(n=57).Patients were divided into the combined group(n=155)and the non combined group(n=85)according to whether they had chronic complications.The basic datas of all patients(gender,course of disease,height,waist circumference,weight,hip circumference,calculation of body mass index,age,diastolic/systolic pressure at rest,waist hip ratio)were collected,the laboratory indicators[fasting blood-glucose,glycosylated hemoglobin,high-density lipoprotein,total cholesterol,triglyceride,low-density lipoprotein,alanine aminotransferase(ALT),aspartate aminotransferase(AST),uric acid,creatinine,urea nitrogen,vitamin D,ferritin,and 2 h postprandial blood glucose]were tested.The basic data and laboratory index levels of diabetes patients with different TyG levels were compared,the correlation between TyG and statistically significant indicators were analyzed,the influencing factors of diabetes complications were analyzed using single factor analysis,the influencing factors of diabetes complications was analyzed using Logistic multiple factor regression analysis,and the predictive value of TyG,vitamin D,ferritin and their combination on diabetes complications was analyzed using receiver operating characteristic(ROC)curve.Results The levels of high density lipoprotein and vitamin D in Q1,Q2,Q3 and Q4 groups decreased gradually,while fasting blood glucose,course of disease,triglyceride,2 h postprandial blood glucose,body mass index,low density

关 键 词：TyG 血糖水平 维生素D 铁代谢失衡 预测价值 

分 类 号：R587.1[医药卫生—内分泌]