特发性膜性肾病患者的临床特征与肾小管间质病变的相关性分析  

作　　者：冯晓霞 黄小燕 戚晨云 陈钦[2] 

机构地区：[1]浙江中医药大学,310053 [2]浙江省立同德医院,310012

出　　处：《浙江临床医学》2024年第8期1208-1210,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省中医药科技计划项目(2023ZL028)。

摘　　要：目的探讨肾小管间质病变与特发性膜性肾病(IMN)患者的临床及病理特征的相关性。方法回顾性分析2011年至2022年88例IMN患者的临床资料,根据肾小管间质病变程度半定量评分将患者分为轻度、中度和重度病变组。分析三组患者临床及肾脏病理特点对肾小管间质病变的影响。结果三组年龄、收缩压、血肌酐及甘油三酯水平、肾小球病变及免疫复合物沉积的程度比较,差异有统计学意义(P<0.05)。多因素线性回归分析甘油三酯水平及新月体形成是影响肾小管间质病变程度的独立危险因素。结论IMN患者的肾小管间质病变受多种因素影响,甘油三酯水平和新月体形成是影响肾小管间质病变程度的独立危险因素。Objective To explore the correlation between the clinical and pathological characteristics of idiopathic membranous nephropathy(IMN)and renal tubulointerstitial lesions.Methods The clinical data of 88 IMN patients from 2011 to 2022 were retrospectively analyzed.The patients were divided into the mild disease group,the moderate disease group and the severe disease group according to the semi-quantitative score of the severity of tubulointerstitial lesions.The effects of clinical and renal pathological characteristics on renal tubulointerstitial lesions in the three groups were analyzed and compared.Results Comparison of age,systolic blood pressure,blood creatinine and triglyceride levels,extent of glomerular lesions and immune complex deposition among the three groups,with statistically significant differences(P<0.05).Multifactor linear regression analysis showed that triglyceride level and crescent formation were independent risk factors affecting the degree of renal tubulointerstitial lesions.Conclusion The renal tubulointerstitial lesions in IMN patients are affected by many factors,and the level of triglyceride and crescent formation are independent risk factors affecting the degree of renal tubulointerstitial lesions.

关 键 词：特发性膜性肾病 肾小管间质病变 临床特征 线性回归分析 

分 类 号：R692[医药卫生—泌尿科学]