血清LHR、SAA与ACS患者颈动脉粥样斑块稳定性的相关性分析  

作　　者：季超霞 汪健 陈铁龙[2] 

机构地区：[1]浙江中医药大学,310053 [2]浙江中医药大学附属杭州市中医院,310007

出　　处：《浙江临床医学》2024年第8期1221-1223,共3页Zhejiang Clinical Medical Journal

基　　金：杭州市生物医药和健康产业扶持科技专项(2021WJCY002)。

摘　　要：目的探讨低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值(LHR)、血清淀粉酶样蛋白A(SAA)与急性冠脉综合症(ACS)患者颈动脉粥样斑块稳定性的相关性。方法选取2022年1月至2023年1月ACS患者147例和健康对照患者30例,根据颈动脉B超结果将ACS患者分为不稳定斑块组、稳定斑块组及无斑块组。比较ACS三个亚组一般临床资料及血清LHR、SAA水平;评估ACS患者颈动脉斑块性质与两种血清因子的相关性。结果三组患者血清SAA、LHR、IMT比较,差异有统计学意义(P<0.05)。血清LHR、SAA与IMT均呈正相关。ROC曲线分析显示血清LHR、SAA对ACS患者不稳定斑块具有诊断意义(P<0.05),且2者联合诊断价值优于单项,AUC值达0.753。结论ACS患者血清SAA、LHR与颈动脉粥样硬化斑块形成及稳定性相关,可作为早期识别不稳定斑块的诊断指标。Objective To study the relationship between the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol(LHR),serum amylase like protein A(SAA)and the stability of carotid atherosclerotic plaque in patients with acute coronary syndrome(ACS).Methods 177 patients with ACS were collected from Hangzhou Traditional Chinese Medicine Hospital from January 2022 to January 2023,and were divided into the unstable plaque group,the stable plaque group,and the non-plaque group based on carotid ultrasound results.The general clinical data and serum LHR and SAA levels of three groups were compared.The correlation between the nature of carotid artery plaques and two serum factors in ACS patients was evaluated.Results Comparison of serum SAA and LHR among three groups of patients showed that:unstable plaque group>stable plaque group>non-plaque group(P<0.05).There was a positive correlation between serum LHR,SAA,and IMT.The ROC curve analysis showed that serum LHR and SAA had diagnostic significance for unstable plaques in ACS patients(P<0.05).Moreover,the combined diagnostic value of the two was superior to that of a single item,with an AUC value of 0.753.Conclusion Serum SAA and LHR in ACS patients are related to the formation and stability of carotid atherosclerotic plaque,which provides a new diagnostic index for early identification of unstable plaque.

关 键 词：急性冠脉综合症 SAA LHR 颈动脉内中膜厚度 颈动脉斑块 

分 类 号：R541.4[医药卫生—心血管疾病]