益气养阴汤联合二甲双胍和厄贝沙坦治疗气阴两虚证2型糖尿病合并高血压疗效观察  

Efficacy of Yiqi Yangyin decoction combined with metformin and irbesartan in treating type 2 diabetes complicated by hypertension with qi and yin deficiency syndrome

作　　者：肖美霞 施胜铭[1] 吴奇红[2] 姚家芳 Xiao Meixia;Shi Shengming;Wu Qihong;Yao Jiafang(Department of General Medicine,The First People's Hospital of Huzhou,Huzhou 313000,Zhejiang Province,China;Department of Endocrinology,The First People's Hospital of Huzhou,Huzhou 313000,Zhejiang Province,China;Department of Cardiology,The First People's Hospital of Huzhou,Huzhou 313000,Zhejiang Province,China)

机构地区：[1]湖州市第一人民医院全科医学科,湖州313000 [2]湖州市第一人民医院内分泌科,湖州313000 [3]湖州市第一人民医院心内科,湖州313000

出　　处：《中国基层医药》2024年第8期1188-1192,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省湖州市科技计划(2022GYB35)。

摘　　要：目的:观察益气养阴汤联合二甲双胍和厄贝沙坦治疗气阴两虚证2型糖尿病合并高血压的临床疗效。方法:采用病例对照研究,回顾性分析湖州市第一人民医院2021年2月至2023年4月收治的气阴两虚证2型糖尿病合并高血压患者92例的临床资料,根据治疗方式不同将患者分为对照组、观察组各46例。对照组采用二甲双胍联合厄贝沙坦治疗,观察组在对照组治疗的基础上,加服益气养阴汤治疗。两组疗程1个月。观察两组临床疗效,比较两组治疗前后中医证候积分、血糖、血压的变化及不良反应发生情况。结果:观察组总有效率为93.48%(43/46),高于对照组的82.61%(38/46)(χ^(2)=5.63,P<0.05)。治疗后,观察组中医证候积分为(9.43±2.11)分,低于对照组的(12.11±2.32)分(t=11.34,P<0.001);观察组空腹血糖、餐后2 h血糖、糖化血红蛋白分别为(7.51±1.34)mmol/L、(9.06±2.11)mmol/L、(6.23±0.76)%,均低于对照组的(8.75±2.12)mmol/L、(11.15±2.43)mmol/L、(7.11±1.02)%(t=4.13、6.14、4.01,均P<0.05);观察组收缩压为(125.48±8.14)mmHg(1 mmHg=0.133 kPa),低于对照组的(131.32±9.22)mmHg(t=6.76,P<0.001)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:益气养阴汤联合二甲双胍和厄贝沙坦治疗气阴两虚证2型糖尿病合并高血压的临床疗效显著,能有效降低中医证候积分,改善患者的血糖和血压水平,且不良反应发生率较低。Objective To investigate the clinical efficacy of Yiqi Yangyin decoction combined with metformin and irbesartan in treating type 2 diabetes complicated by hypertension with qi and yin deficiency syndrome.Methods A case-control study was performed to retrospectively analyze the clinical data of 92 patients with type 2 diabetes complicated by hypertension with qi and yin deficiency syndrome.These patients received treatment at the First People's Hospital of Huzhou from February 2021 to April 2023.They were divided into two groups,with 46 patients in each group,based on different treatment methods.The control group received metformin and irbesartan,while the observation group was treated with Yiqi Yangyin decoction in addition to the treatment provided to the control group.Both groups underwent treatment for 1 month.The clinical efficacy of the two groups was evaluated,and the changes in traditional Chinese medicine symptom scores,blood glucose levels,blood pressure,and the occurrence of adverse reactions were compared between the two groups before and after treatment.Results The total response rate of the observation group was 93.48%(43/46),which was significantly higher than that of the control group[82.61%(38/46),χ^(2)=5.63,P<0.05).After treatment,the traditional Chinese medicine symptom score for the observation group was(9.43±2.11)points,which was significantly lower than that of the control group[(12.11±2.32)points,t=11.34,P<0.001].The fasting blood glucose,2-hour postprandial blood glucose,and glycosylated hemoglobin levels in the observation group were(7.51±1.34)mmol/L,(9.06±2.11)mmol/L,and(6.23±0.76)%,respectively,all of which were significantly lower than those in the control group[(8.75±2.12)mmol/L,(11.15±2.43)mmol/L,(7.11±1.02)%,t=4.13,6.14,4.01,all P<0.05].The systolic blood pressure in the observation group was(125.48±8.14)mmHg(1 mmHg=0.133 kPa),which was significantly lower than that in the control group[(131.32±9.22)mmHg,t=6.76,P<0.001].The difference in the incidence of adverse reactions

关 键 词：糖尿病 2型 高血压 药物疗法 联合 医学 中国传统 血糖 血红蛋白A 糖基化 血压 药物相关性副作用和不良反应 

分 类 号：R587.2[医药卫生—内分泌] R544.1[医药卫生—内科学]