五灵胶囊治疗酒精性肝病的效果  

Efficacy of Wuling Capsules in treating alcoholic liver disease

作　　者：袁德胜 张振江 梁恩富 段煜 李凯 袁玲 YUAN Desheng;ZHANG Zhenjiang;LIANG Enfu;DUAN Yu;LI Kai;YUAN Ling(Department of Integrated Traditional Chinese and Western Medicine Hepatology,Dalian Public Health Clinical Center,Dalian 116012,China;Department of Infectious Diseases,Suqian Hospital,Jiangsu Provincial People’s Hospital,Suqian 223800,China;Department of Hepatology,Dalian Public Health Clinical Center,Dalian 116012,China)

机构地区：[1]大连公共卫生临床中心中西医结合肝病科,大连116012 [2]江苏省人民医院宿迁医院感染病科,宿迁223800 [3]大连公共卫生临床中心肝病科,大连116012

出　　处：《西北药学杂志》2024年第5期26-32,共7页Northwest Pharmaceutical Journal

基　　金：大连市医学科学研究计划项目(编号:2106Z1015)。

摘　　要：目的 探讨五灵胶囊治疗酒精性肝病的效果。方法 以2022年1月-2024年1月收治的酒精性肝病患者240例作为研究对象。根据治疗方案不同分为2组,对照组使用护肝片常规治疗,研究组使用五灵胶囊治疗。比较2组患者的临床治疗总有效率、肝功能、FibroScan肝硬度值、肝纤维化指标[Ⅲ型前胶原(procollagen Ⅲ,PCⅢ)、Ⅳ型胶原(collage type Ⅳ,C-Ⅳ)、层黏连蛋白(laminin,LN)和透明质酸(hyaluranic acid,HA)]及不良反应发生率。结果 研究组的临床治疗总有效率高于对照组(95.00%vs. 81.86%,P<0.05);治疗后2组肝功能指标血清总胆红素(total bilirubin,TBiL)、γ-谷氨酰转肽酶(glutamyltranspeptidase,GGT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)和丙氨酸氨基转移酶(alanine aminotransferase,ALT)水平,FibroScan肝硬度值[肝硬度值(liver stiffness measurenet,LSM)、受控衰减指数(contralled attenuation parameter, CAP)]均降低,且研究组均低于对照组,差异均有统计学意义(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 五灵胶囊治疗酒精性肝病,临床疗效理想且安全性高,能够改善患者的肝功能和肝纤维化。Objective To explore the efficacy of Wuling Capsules in the treatment of alcoholic liver disease.Methods 240 patients with alcoholic liver disease admitted to the hospital from January 2022 to January 2024 were enrolled and divided into 2 groups according to different treatment regimes.The control group received routine treatment with Liver Protection Tablets(Hugan Tablets),while the study group received Wuling Capsules.The total effective rate of clinical treatment,liver function,FibroScan liver hardness value[liver stiffness measurement(LSM)and the controlled attenuation parameter(CAP)],liver fibrosis indicators such as procollagenⅢ(PCⅢ),collagen typeⅣ(C-Ⅳ),laminin(LN),and hyaluronic acid(HA),and adverse reaction rate between the 2 groups were compared.Results The total effective rate in the study group was higher than that in the control group(96.67%vs.75.56%,P<0.05).After treatment,the liver function indicators,i.e.the levels of serum total bilirubin(TBiL),glutamyl transpeptidase(GGT),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),FibroScan liver hardness values[liver stiffness measurenet(LSM),contralled attenuation parameter(CAP)]in both groups decreased,and the study group was lower than the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Wuling Capsules have ideal clinical efficacy and high safety in treating alcoholic liver disease,and can improve patients’liver function and prevent liver fibrosis.

关 键 词：五灵胶囊 酒精性肝炎 肝纤维化指标 FibroScan肝硬度值 

分 类 号：R975[医药卫生—药品]