右美托咪定硬膜外辅助间歇用药对初产妇分娩镇痛的效果  

Effect of dexmedetomidine epidural adjuvant intermittent medication on labor analgesia in primiparous women

作　　者：张剑勇[1] 杨奇星[1] 郭晓婧 ZHANG Jianyong;YANG Qixing;GUO Xiaojing(Department of Anesthesiology,Linfen People’s Hospital,Linfen 041000,China)

机构地区：[1]临汾市人民医院麻醉科,临汾041000

出　　处：《西北药学杂志》2024年第5期218-222,共5页Northwest Pharmaceutical Journal

基　　金：山西省自然科学基金项目(编号:201901D121180)。

摘　　要：目的 探讨应用低剂量右美托咪定辅助间歇用药对初产妇分娩镇痛的效果。方法 以收治的150例初产妇作为研究对象,随机分为对照组与研究组,各75例。对照组采用常规硬膜外麻醉方案,研究组在对照组麻醉方案的基础上给予低剂量右美托咪定硬膜外辅助间歇用药。分别记录实施镇痛前(t_0)、镇痛30 min后(t_1)及胎儿娩出后(t_2)产妇的疼痛感受[视觉疼痛模拟评分法(visual pain simulation score,VAS)]变化,对比2组临床基本指标(镇痛时间、麻醉药物用量和产后出血量)及各产程(第一、第二和第三产程)时间,观察2组产妇不良反应的发生情况。结果 研究组的镇痛效果较对照组更高(P<0.05),研究组各项临床指标、第二产程和第三产程时长均较对照组更(短)(P<0.05),2组产妇第一产程时间及产后并发症比较差异无统计学意义(P>0.05)。结论 初产妇分娩过程中间歇采用低剂量右美托咪定辅助麻醉可有效提高镇痛效果,减少产妇麻醉药物依赖,促进产妇分娩的顺利进行。Objective To investigate the effect of low-dose dexmedetomidine epidural adjuvant intermittent medication on labor pain in primiparous women.Methods 150 primipara were enrolled and randomly divided into control group and study group,with 75 cases in each.The control group was given routine epidural anesthesia,while the study group was given low-dose dexmedetomidine as an auxiliary intermittent epidural medication.The changes of pain perception[visual pain simulation score(VAS)]of the 2 groups before analgesia(t0),30 minutes after analgesia(t1)and after fetal delivery(t2)were recorded respectively.The clinical basic indicators(analgesia time,the amount of anesthetic drugs used and the amount of postpartum hemorrhage)and the duration of each stage of labor(the first stage of labor,the second stage of labor and the third stage of labor)of the 2 groups were compared,and the adverse reactions of the 2 groups were observed.Results The analgesic effect of the study group was higher than that of the control group(P<0.05),and the clinical indicators,the duration of the second and third stages of labor in the study group were lower(shorter)than that of the control group(P<0.05).There was no significant difference between the 2 groups in the length of the first stage of labor and the occurrence of postpartum complications(P>0.05).Conclusion Adjuvant anesthesia with low-dose dexmedetomidine during delivery of primipara can effectively improve the analgesic effect of patients,reduce the dependence of primipara on narcotic drugs,and promote the smooth delivery of primipara.

关 键 词：右美托咪定 硬膜外麻醉 辅助用药 初产妇 分娩镇痛 

分 类 号：R984[医药卫生—药品]