强直性脊柱炎患者髋关节滑膜组织中SOST、u-PA、β-catenin表达水平及临床意义  

Expression Levels and Clinical Significance of SOST,u-PA andβ-catenin in Synovial Tissue of Hip Joint in Patients with Ankylosing Spondylitis

作　　者：丁帅 张广泉 高延征 王红强 余正红 李昱 DING Shuai;ZHANG Guangquan;GAO Yanzheng;WANG Hongqiang;YU Zhenghong;LI Yu(Spinal and Spinal Surgery Department,Henan Provincial People’s Hospital,Zhengzhou University People’s Hospital,Henan University People’s Hospital,Zhengzhou 450003,China;Department of Orthopedics,Henan Provincial People’s Hospital,Zhengzhou University People’s Hospital,Henan University People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院脊柱脊髓外科,郑州大学人民医院,河南大学人民医院,河南郑州450003 [2]河南省人民医院骨科,郑州大学人民医院,河南大学人民医院,河南郑州450003

出　　处：《河南医学研究》2024年第18期3295-3299,共5页Henan Medical Research

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20230041)。

摘　　要：目的探讨强直性脊柱炎(AS)患者髋关节滑膜组织中骨硬化蛋白(SOST)、尿激酶型纤溶酶原激活物(u-PA)、β-连环蛋白(β-catenin)表达水平及临床意义。方法选取2018年7月至2023年6月在河南省人民医院诊治的80例AS患者作为病例组,并选取同期80例创伤骨折患者作为对照组,比较病例组和对照组、不同强直性脊柱炎疾病活动度评分(ASDAS)、Bath强直性脊柱炎疾病活动性指数(BASDAI)、Bath强直性脊柱炎功能指数(BASFI)髋关节滑膜组织中SOST、u-PA、β-catenin表达,并分析髋关节滑膜组织中SOST、u-PA、β-catenin表达对AS的预测价值。结果病例组髋关节滑膜组织中SOST、u-PA、β-catenin表达高于对照组(P<0.05)。极高疾病活动度、高疾病活动度患者髋关节滑膜组织中SOST、u-PA表达高于缓解期患者(P<0.05),极高疾病活动度患者髋关节滑膜组织中β-catenin表达高于缓解期患者(P<0.05);BASDAI≥5分患者髋关节滑膜组织中SOST、u-PA、β-catenin表达高于BASDAI<5分患者(P<0.05)。受试者工作特征曲线分析显示,SOST、u-PA、β-catenin及三者联合预测AS的曲线下面积分别为0.861、0.818、0.860、0.905,最佳临界值对应的敏感度、特异度SOST为78.8%、88.7%,u-PA为95.0%、56.2%,β-catenin为68.8%、91.2%,三者联合为92.5%、83.8%。结论AS患者髋关节滑膜组织中SOST、u-PA、β-catenin表达升高,与疾病活动度、病情严重程度有关,髋关节滑膜组织中SOST、u-PA、β-catenin联合对AS具有较高的预测价值。Objective To explore the expression levels of bone sclerostin(SOST),urokinase type plasminogen activator(u-PA)andβ-catenin(β-catenin)in the synovial tissue of hip patients with ankylosing spondylitis(AS).Methods A total of 80 AS patients treated in Henan Provincial People’s Hospital from July 2018 to June 2023 were selected as the case group,and 80 trauma fracture patients during the same period were selected as the control group.The SOST,u-PA,β-catenin expression in the case group and control group,different ankylosing spondylitis disease activity scores(ASDAS),Bath ankylosing spondylitis disease activity index(BASDAI),Bath ankylosing spondylitis functional index(BASFI)were compared,and the predictive value of SOST,u-PA andβ-catenin expression in the synovial tissue of the hip joint for AS were analyzed.Results The expression of SOST,u-PA andβ-catenin in the hip synovial tissue of the case group were higher than those in the control group(P<0.05).The expression of SOST and u-PA in the hip synovial tissue of patients with extremely high disease activity and high disease activity were higher than those of patients in remission(P<0.05).The expression ofβ-catenin in the hip synovial tissue of patients with extremely high disease activity was higher than that of patients in remission stage(P<0.05).SOST,u-PA andβ-catenin expression in the hip synovial tissue of patients with BASDAI≥5 were higher than patients with BASDAI<5(P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve of SOST,u-PA andβ-catenin and their combined prediction were 0.861,0.818,0.860 and 0.905,respectively.The sensitivity and specificity corresponding to the optimal critical values were as follows,SOST was 78.8%,88.7%,u-PA was 95.0%,56.2%,β-catenin was 68.8%,91.2%,and the combination of the three was 92.5%,83.8%.Conclusion The expression of SOST,u-PA andβ-catenin was increased in the synovial tissue of hip patients with AS,which is related to disease activity and disease severity,and the combina

关 键 词：强直性脊柱炎 髋关节 滑膜组织 骨硬化蛋白 尿激酶型纤溶酶原激活物 β-连环蛋白 

分 类 号：R593.2[医药卫生—内科学]