亚低温治疗对重症脑炎患儿的影响  

Influence of Mild Hypothermia Treatment on Children with Severe Encephalitis

作　　者：李娅娅 LI Yaya(Department of Children’s Intensive Care Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院儿童重症医学病区,河南郑州450000

出　　处：《河南医学研究》2024年第18期3334-3338,共5页Henan Medical Research

摘　　要：目的分析亚低温治疗对重症脑炎患儿的影响。方法选取2019年12月至2022年12月郑州大学第一附属医院收治的100例重症脑炎患儿,随机分为观察组和对照组,各组50例。对照组接受常规治疗,观察组在对照组基础上接受亚低温治疗仪治疗。对比两组疗效、症状改善时间(体温恢复时间、肢体活动恢复时间、神志恢复时间、惊厥消失时间、住院时间)、运动功能评定量表(FMA)评分、炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平、神经元特异性烯醇化酶(NSE)、神经胶质特异性蛋白(S100B)水平、不良反应。结果观察组治疗总有效率较对照组高(P<0.05);观察组体温恢复天数、肢体活动恢复天数、神志恢复天数、惊厥消失天数、住院天数较对照组短(P<0.05);治疗后,观察组上肢评分、下肢评分较对照组高(P<0.05);治疗后,观察组CRP、IL-6、IL-8、TNF-α、NSE、S100B水平较对照组低(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论亚低温治疗仪治疗重症脑炎患儿效果确切,可减轻炎症反应,调节NSE、S100B水平,促进症状和肢体运动能力改善,安全性可。Objective To analyze the effect of mild hypothermia therapy on children with severe encephalitis.Methods A total of 100 children with severe encephalitis in the First Affiliated Hospital of Zhengzhou University from December 2019 to December 2022 were randomly divided into observation group and control group,with 50 cases in each group.The control group was given routine treatment,and the observation group was given mild hypothermia treatment based on the control group.The efficacy,symptom improvement time(body temperature recovery time,limb movement recovery time,mental recovery time,convulsion disappearance time,hospitalization time),Motor function assessment scale,FMA score,inflammatory factor[C-reactive protein(CRP)],interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)levels,neuron-specific enolase(neuron-specific enolase,TNF-α),neuron-specific enolase(NSE),glial specific protein(S100B)levels and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The days of body temperature recovery,limb movement recovery,mental recovery,convulsion disappearance and hospitalization in observation group were shorter than those in control group(P<0.05).After treatment,the scores of upper and lower limbs in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of CRP,IL-6,IL-8,TNF-α,NSE and S100B in observation group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The ultra-low temperature therapy device has a definite effect on treating children with severe encephalitis,which can reduce inflammatory reactions,regulate NSE and S100B levels,promote symptom and limb movement improvement,and is safe.

关 键 词：重症脑炎 亚低温治疗仪 肢体运动能力 

分 类 号：R473.5[医药卫生—护理学]