益气化痰活血法治疗心血管代谢性疾病的Meta分析  

Meta-analysis of Boost Qi,Dissolve Phlegm and Invigorate Blood for the Treatment of Cardiovascular Metabolic Diseases

作　　者：董敏 田丁阳 粟裕冬 李慧歆 董波 DONG Min;TIAN Dingyang;SU Yudong;LI Huixin;DONG Bo(Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China)

机构地区：[1]山东中医药大学,济南250014 [2]山东第一医科大学附属省立医院,济南250021

出　　处：《中西医结合心脑血管病杂志》2024年第18期3265-3274,共10页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金项目(No.81570729);泰山学者基金项目(No.ts20190979)。

摘　　要：目的:系统评价益气化痰活血法治疗心血管代谢性疾病的疗效和安全性。方法:计算机检索中英文数据库内收录的关于益气化痰活血法治疗心血管代谢性疾病的随机对照研究(RCTs),采用RevMan 5.4软件进行资料提取和质量评价,并进行Meta分析。结果:共纳入24篇文献,涉及1951例病人,其中观察组980例,对照组971例。Meta分析结果显示,与对照组比较,观察组临床总有效率升高[OR=5.09,95%CI(3.67,7.07),P<0.00001];观察组空腹血糖[MD=-0.68,95%CI(-1.06,-0.30),P=0.0004]、餐后2 h血糖[MD=-1.37,95%CI(-1.62,-1.12),P<0.00001]、糖化血红蛋白[MD=-0.56,95%CI(-0.72,-0.41),P<0.00001]、总胆固醇[MD=-0.69,95%CI(-1.29,-0.08),P=0.03]、三酰甘油[MD=-0.47,95%CI(-0.58,-0.36),P<0.00001]、低密度脂蛋白胆固醇[MD=-0.61,95%CI(-0.72,-0.51),P<0.00001]、白细胞介素-6[SMD=-0.36,95%CI(-0.59,-0.13),P=0.002]、肿瘤坏死因子-α[SMD=-1.16,95%CI(-2.13,-0.19),P=0.02]、C反应蛋白[SMD=-0.83,95%CI(-1.63,-0.04),P=0.04]、体质指数[MD=-0.92,95%CI(-1.33,-0.52),P<0.00001]、中医证候积分[MD=-2.79,95%CI(-3.96,-1.62),P<0.00001]降低,差异均有统计学意义。观察组左室射血分数高于对照组,差异有统计学意义[SMD=1.15,95%CI(0.62,1.69),P<0.0001]。结论:现有证据表明,益气化痰活血法治疗心血管代谢性疾病疗效显著,且不良反应较少。Objective:To systematically evaluate the effect and safety of boost Qi,dissolve phlegm and invigorate blood for the treatment of cardiovascular metabolic diseases.Methods:Randomized controlled trials(RCTs)for the treatment of cardiovascular metabolic diseases by boost Qi,dissolve phlegm and invigorate blood were searched from Chinese and English databases.Data extraction and quality evaluation were conducted by RevMan 5.4 software,and Meta-analysis was performed.Results:A total of 24 literatures were included,including 1951 patients,with 980 patients in the observation group and 971 patients in the control group.The results of Meta-analysis showed that compared with the control group,the clinical efficacy in the observation group was better(OR=5.09,95%CI 3.67-7.07,P<0.00001);fasting blood glucose(MD=-0.68,95%CI-1.06--0.30,P=0.0004),2 h postprandial blood glucose(MD=-1.37,95%CI-1.62--1.12,P<0.00001),glycosylated hemoglobin(MD=-0.56,95%CI-0.72--0.41,P<0.00001),total cholesterol(MD=-0.69,95%CI-1.29--0.08,P=0.03),triacylglycerol(MD=-0.47,95%CI-0.58--0.36,P<0.00001),low density lipoprotein cholesterol(MD=-0.61,95%CI-0.72--0.51,P<0.00001),interleukin-6(SMD=-0.36,95%CI-0.59--0.13,P=0.002),tumor necrosis factor-α(SMD=-1.16,95%CI-2.13--0.19,P=0.02),C-reactive protein(SMD=-0.83,95%CI-1.63--0.04,P=0.04),body mass index(MD=-0.92,95%CI-1.33--0.52,P<0.00001),traditional chinese medicine syndrome score(MD=-2.79,95%CI-3.96--1.62,P<0.00001)in the observation group was less than that of control group,and the differences were statistically significant.Left ventricular ejection fraction in the observation group was more than that in the control group,and the difference was statistically significant(SMD=1.15,95%CI 0.62-1.69,P<0.0001).Conclusion:The current evidence showed that boost Qi,dissolve phlegm and invigorate blood for the treatment of cardiovascular metabolic diseases was effective,with fewer adverse reactions.

关 键 词：心血管代谢性疾病 益气化痰活血法 疗效 安全性 META分析 

分 类 号：R259[医药卫生—中西医结合]