张家港市居民乙型肝炎病毒新发感染状况调查  

Investigation on new hepatitis B virus infection among residents in Zhangjiagang city

作　　者：丁玲云 姚敏芳[2] 沈艳[1] 刘宇畅[1] 季燕 姚轶男 DING Lingyun;YAO Minfang;SHEN Yan;LIU Yuchang;JI Yan;YAO Yinan(Department of Infectious Disease Control and Prevention,Zhangjiagang Center for Disease Control and Prevention,Suzhou,Jiangsu 215600,China;Central Department,Zhangjiagang Center for Disease Control and Prevention,Suzhou,Jiangsu 215600,China)

机构地区：[1]张家港市疾病预防控制中心传染病防制科,江苏苏州215600 [2]张家港市疾病预防控制中心中心部,江苏苏州215600

出　　处：《热带医学杂志》2024年第8期1200-1204,1214,共6页Journal of Tropical Medicine

基　　金：国家科技重大专项(2018ZX10715-002);张家港市卫生青年科技项目(ZJGQNKJ202020)。

摘　　要：目的了解江苏张家港市乙型肝炎病毒(HBV)新发感染状况,分析其感染的影响因素,为制定乙肝防控策略提供科学依据。方法选取“十一五”至“十二五”期间参加“张家港市乙型肝炎综合防治研究”且乙型肝炎表面抗原(HBsAg)筛查结果为阴性的80613名居民作为研究对象,在“十三五”期间对其随访调查并进行乙肝血清学检测。结果最终完成随访调查的共有72149人,随访率为89.50%,乙型肝炎病毒累积新发感染率为1.72%,乙型肝炎表面抗体(抗-HBs)总体阳性率为44.81%。男性和女性HBV新发感染率分别为1.78%、1.63%,抗-HBs阳性率分别为44.95%、44.63%,差异均无统计学意义(χ^(2)=2.389、0.758,P=0.122、0.384)。<20、20~<40、40~<60、60~<80、80~岁HBV新发感染率依次为1.14%、1.51%、2.00%、1.73%、1.40%,抗-HBs阳性率依次为14.77%、42.71%、49.60%、44.56%、40.36%,差异均有统计学意义(χ^(2)=15.378、339.340,P均<0.001)。有乙肝家族史的人群HBV新发感染率(4.51%)高于无乙肝家族史的人群(1.68%),未接种乙肝疫苗的人群HBV新发感染率(1.79%)高于已接种的人群(1.18%),差异均有统计学意义(χ^(2)=49.771、12.310,P均<0.001)。多因素logistic回归分析结果显示,40~<60岁(OR=1.548,P<0.001)、有乙肝家族史(OR=3.103,P<0.001),未接种乙肝疫苗(OR=1.621,P<0.001)是HBV新发感染的独立危险因素。结论张家港市居民HBV新发感染率较高,抗-HBs总体阳性率较低,应加强成人乙肝疫苗接种,积极开展高危人群的HBsAg筛查。Objective To investigate the status of new hepatitis B virus(HBV)infection in Zhangjiagang city,Jiangsu province,and analyze the influencing factors of infection,so as to provide scientific basis for the development of hepatitis B prevention and control strategy.Methods A total of 80613 residents who participated in the Comprehensive Prevention and Treatment of hepatitis B in Zhangjiagang city during“The eleventh Five⁃Year Plan”and“The twelfth Five⁃Year Plan”and the screening results of hepatitis B surface antigen(HBsAg)were negative were selected as the study objects,and the follow⁃up investigation and hepatitis B serological detection were conducted during“The thirteenth Five⁃Year Plan”period.Results A total of 72149 people were followed up,the follow⁃up rate was 89.50%,the cumulative new infection rate of HBV was 1.72%,and the overall positive rate of anti⁃HBs was 44.81%.The new infection rates of HBV in males and females were 1.78%and 1.63%,respectively,and the positive rates of anti⁃HBs were 44.95%and 44.63%,respectively;the differences were not statistically significant(χ^(2)=2.389,0.758,P=0.122,0.384).The new infection rates of HBV in<20,20-<40,40-<60,60-<80 and 80-years old were 1.14%,1.51%,2.00%,1.73%and 1.40%,respectively,and the positive rates of anti⁃HBs were 14.77%,42.71%,49.60%,44.56%,40.36%,respectively,the differences were statistically significant(χ^(2)=15.378,339.340;all P<0.001).The rate of new HBV infection in the group with a family history of hepatitis B(4.51%)was higher than that in the group without a family history of hepatitis B(1.68%),and the rate of new HBV infection in the group without hepatitis B vaccine(1.79%)was higher than that in the group with vaccination(1.18%),the differences were statistically significant(χ^(2)=49.771,12.310;all P<0.001).Multivariate logistic regression analysis showed that 40-<60 years old(OR=1.548,P<0.001),family history of hepatitis B(OR=3.103,P<0.001),and no hepatitis B vaccination(OR=1.621,P<0.001)were independent influenc

关 键 词：乙型肝炎病毒 新发感染 乙型肝炎表面抗体 乙肝疫苗接种 

分 类 号：R512.62[医药卫生—内科学]