B细胞活化因子/增殖诱导配体对特发性炎性肌病B细胞影响的研究进展  

Advances in Effect of B Cell Activating Factor/A Proliferation-inducing Ligand on B Cell Function in Idiopathic Inflammatory Myopathies

作　　者：肖尧 于飞[1] 胡绍先 XIAO Yao;YU Fei;HU Shaoxian(Department of Rheumatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院风湿免疫科,武汉市430030

出　　处：《医学分子生物学杂志》2024年第5期492-496,共5页Journal of Medical Molecular Biology

摘　　要：特发性炎性肌病(idiopathic inflammatory myopathies,IIM)是免疫介导肌肉炎症为主要特征的系统性自身免疫性疾病。淋巴细胞是IIM发病机制中的关键免疫调节细胞,可引起自身免疫和炎症反应。B细胞活化因子(B cell activating factor,BAFF)/增殖诱导配体(a proliferation-inducing ligand,APRIL)是肿瘤坏死因子超家族成员,BAFF/APRIL通过与相应受体结合,影响B细胞的增殖、成熟和分化,浆细胞的存活,免疫球蛋白类别的转换,从而调控免疫反应。研究发现,BAFF/APRIL参与多种自身免疫性疾病的发病机制,与IIM发生和发展密切相关,文章对BAFF/APRIL在IIM的研究进展进行综述。Idiopathic inflammatory myopathy(IIM)is a systemic autoimmune disease mainly characterized by immune-mediated muscle inflammation.Lymphocytes are key immunoregulatory cells in IIM pathogenesis that mediate autoimmune and inflammatory responses.B cell activating factor(BAFF)/a proliferation-inducing ligand(APRIL)are members of the tumor necrosis factor superfamily.By binding to the corresponding receptors,BAFF/APRIL affects the proliferation,maturation and differentiation of B cells,the survival of plasma cells,and thus regulates the immune response.BAFF/APRIL is involved in the pathogenesis of many autoimmune diseases and is closely related to the occurrence and development of IIM.This article intends to review the research progress of BAFF/APRIL in IIM.

关 键 词：特发性炎性肌病 B细胞活化因子 增殖诱导配体 B细胞 

分 类 号：R593.26[医药卫生—内科学]