自体富血小板血浆卵巢内注射治疗卵巢储备功能减退的疗效观察  

Therapeutic effect of intraovarian injection of autologous platelet-rich plasma for the treatment of diminished ovarian reserve

作　　者：吴洪波 刘艳美 张昭 刘俐伶 WU Hongbo;LIU Yanmei;ZHANG Zhao;LIU Liling(Qinzhou Maternal and Child Health Hospital,Qinzhou 535000,China;Reproductive Medical and Genetic Center,The People’s Hospital of GuangXi Zhuang Autonomous Region)

机构地区：[1]钦州市妇幼保健院生殖医学中心,广西钦州535000 [2]广西壮族自治区人民医院生殖医学遗传与研究中心

出　　处：《中国输血杂志》2024年第9期998-1002,1012,共6页Chinese Journal of Blood Transfusion

基　　金：广西壮族自治区中医药局自筹经费课题(GXZYN20220576);广西中医药适宜技术开发与推广项目(GZSY22-55);钦州市科学研究与技术开发计划项目(20223630)。

摘　　要：目的探讨富血小板血浆卵巢内注射治疗卵巢功能减退患者的有效性,旨在为卵巢储备功能减退的治疗提供新的诊疗思路。方法收集2021年1月-2023年12月在钦州市妇幼保健院生殖医学中心行自体富血小板血浆卵巢内注射的卵巢储备功能减退患者22名,其中12名进行了辅助生殖技术助孕,观察患者治疗后的抗缪勒管激素、窦卵泡数、基础促卵泡刺激素、基础促黄体生成素、基础雌二醇水平。结果22名患者经治疗后AMH、AFC、基础FSH、基础LH、基础E2水平均较治疗前有所改善;接受辅助生殖助孕的12名患者中,有2名因卵巢反应不良取消了试管周期。10名患者获得了胚胎,其中有5名患者获得了优质的胚胎。结论自体富血小板血浆卵巢内注射能有效的改善卵巢储备功能减退患者的卵巢储备功能。Objective To explore the effectiveness of intraovarian injection of platelet-rich plasma(PRP)in the treatment of patients with diminished ovarian reserve(DOR),aiming to provide new diagnostic and therapeutic ideas for the treatment.Methods A total of 22 patients with DOR who underwent autologous PRP ovarian injection at the Reproductive Medical and Genetic Center of Qinzhou Maternal and Child Health Hospital from January 2021 to December 2023 were collected.Among them,12 patients underwent assisted reproductive technology for pregnancy.The patient′s anti-Müllerian hormone(AMH),antral follicle count(AFC),basal follicle-stimulating hormone(FSH),basal luteinizing hormone(LH)and basal estradiol(E2)levels were observed.Results The levels of AMH,AFC,basal FSH,basal LH and basal E2 in 22 patients improved after treatment compared with those before treatment.Of the 12 patients who received assisted reproduction,2 had IVF cycle canceled due to poor ovarian reaction.Ten patients obtained embryos,of which 5 obtained high-quality embryos.Conclusion Intraovarian injection of autologous PRP can effectively improve ovarian reserve function in patients with DOR.

关 键 词：富血小板血浆 卵巢储备功能减退 辅助生殖 

分 类 号：R331.143[医药卫生—人体生理学] R714.222[医药卫生—基础医学]