中药治疗功能性便秘潜在机制研究进展  

Research progress in the potential mechanism of Chinese medicine in the treatment of functional constipation

作　　者：张亚薇 董洋 潘丽红 陈倩 王丹 刘梦扬 吴昱铮 王涛[1,3] ZHANG Yawei;DONG Yang;PAN Lihong;CHEN Qian;WANG Dan;LIU Mengyang;WU Yuzheng;WANG Tao(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Lunan Pharmaceutical Group Co.Ltd.,Linyi 276006,China;State Key Laboratory of Component-based Chinese Medicine,Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中医药研究院,天津301617 [2]鲁南制药集团股份有限公司经方与现代中药融合创新全国重点实验室,临沂276006 [3]天津中医药大学中医药研究院,组分中药国家重点实验室,天津301617

出　　处：《天津中医药》2024年第9期1206-1213,共8页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074118);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202009)。

摘　　要：功能性便秘是慢性便秘中最常见的类型,属于慢性功能性肠道疾病,具有反复发作,迁延难愈的特点。虽然,短期便秘不会危及生命,但是便秘引起的胃肠道不适严重影响患者的生活质量,且长期便秘可能增加结直肠肿瘤发生率。中药在增强胃肠动力,调节肠道蠕动节律等方面具有多成分、多靶点综合调节的明显优势。文章主要总结近年来中药在治疗功能性便秘中的应用和机制研究进展,为进一步研究中药治疗功能性便秘的药效和机制提供参考。Functional constipation is the most common type of chronic constipation,which belongs to chronic functional intestinal diseases,characterized by recurrent episodes and difficult to be cured.Although short-term constipation is not life-threatening,gastrointestinal discomfort caused by constipation seriously affects patients’quality of life,and long-term constipation may increase the incidence of colorectal tumors.Traditional Chinese medicine has obvious advantages in enhancing gastrointestinal motility and regulating intestinal peristalsis rhythm.This article summarizes the research progress of the application and mechanism research of traditional Chinese medicine in the treatment of functional constipation in recent years,provides reference for further research on the efficacy and mechanism of traditional Chinese medicine in the treatment of functional constipation.

关 键 词：中药 功能性便秘 作用机制 

分 类 号：R442.2[医药卫生—诊断学]