菟丝子化学成分、药理作用研究进展及其质量标志物(Q-Marker)预测  

Research progress on chemical constituents,pharmacological effects of Cuscutae Semen and its quality marker prediction

作　　者：陈鲁宁 胡扬[1] 辛国松 陈鹰翔 宗政 宋辉[1] 孙向明 徐蓓蕾[1] 张文君[1] 王昊 杨智惠 李文兰[1] CHEN Luning;HU Yang;XIN Guosong;CHEN Yingxiang;ZONG Zheng;SONG Hui;SUN Xiangming;XUBeilei;ZHANG Wenjun;WANG Hao;YANG Zhihui;LI Wenlan(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076

出　　处：《中草药》2024年第15期5298-5314,共17页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省重点研发计划项目(2022ZX02C08);黑龙江省“双一流”学科协同创新成果建设项目(LJGXCG2022-096)。

摘　　要：菟丝子Cuscutae Semen始载于《神农本草经》,具有补益肝肾、固精缩尿、明目安胎的功效,主要含有黄酮类、木脂素类、多糖等化学成分。现代研究表明,菟丝子具有保护生殖系统、免疫调节、抗肿瘤等药理作用。《中国药典》2020年版仅将金丝桃苷作为菟丝子质量控制标准,对菟丝子质量整体评价较为单一且专属性差。通过对菟丝子的本草考证、化学成分、药理作用和临床应用进行综述,并基于质量标志物(quality marker,Q-Marker)的概念,从植物亲缘性、化学成分可测性、入血成分、药对配伍等进行Q-Marker预测。初步推测金丝桃苷、紫云英苷、异鼠李素、山柰酚、异槲皮苷、槲皮素、绿原酸、阿魏酸、芝麻素等成分为菟丝子主要的Q-Marker,为建立和完善菟丝子质量评价体系提供参考。Tusizi(Cuscutae Semen)was first recorded in Shennong’s Classic of Materia Medica,which has the effects of tonifying liver and kidney,solidifying essence,reducing urine,improving eyesight and stabilising foetus.Its main chemical components include flavonoids,lignans,polysaccharides,etc.Modern research indicated that Cuscutae Semen has multiple pharmacological effects such as reproductive protection,immunomodulation and anti-tumour.The 2020 edition of Chinese Pharmacopoeia only takes the content of hyperoside as the quality control standard of Cuscutae Semen,which makes the overall quality evaluation of Cuscutae Semen relatively single and poor in specificity.In this paper,textual research,chemical composition,pharmacological effects and clinical applications of Cuscutae Semen were reviewed,the quality marker(Q-Marker)of Cuscutae Semen were predicted and analyzed in terms of plant affinities,chemical composition measurability,blood components and compatibility based on the concept of Q-Marker.It was preliminarily predicted that hyperoside,astragalin,isorhamnetin,kaempferol,isoquercitrin,quercetin,chlorogenic acid,ferulic acid and sesamin can be used as the main Q-Markers of Cuscutae Semen,which provides reference for the establishment and improvement of the quality evaluation system of Cuscutae Semen.

关 键 词：菟丝子 质量标志物 质量标准 金丝桃苷 紫云英苷 山柰酚 绿原酸 芝麻素 

分 类 号：R285[医药卫生—中药学]