提升姜黄素疗效的策略及技术研究进展  

Research progress on strategies and techniques for improving therapeutic effect of curcumin

作　　者：陈榕 颜烨[1,2] 何梓炫 黄小红 林昭妍[1,2] CHEN Rong;YAN Ye;HE Zixuan;HUANG Xiaohong;LIN Zhaoyan(College of Animal Sciences,Fujian Agriculture and Forestry University,Fuzhou 350002,China;University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province/Key Laboratory for Integrated Chinese Traditional Veterinary Medicine and Animal Healthcare in Fujian Province,Fujian Agriculture and Forestry University,Fuzhou 350002,China)

机构地区：[1]福建农林大学动物科学学院,福建福州350002 [2]中西兽医结合与动物保健福建省高校重点实验室/福建省兽医中药与动物保健重点实验室,福建农林大学,福建福州350002

出　　处：《中草药》2024年第15期5315-5330,共16页Chinese Traditional and Herbal Drugs

基　　金：2021福建省科技厅重大专项专题项目(2021NZ029008)。

摘　　要：姜黄素是从姜黄Curcuma longa中提取出的多酚类天然化合物,其医疗价值已被发掘超过30年。低剂量的姜黄素就能在抗肿瘤、抗炎、抗氧化等方面发挥显著的作用,但是由于其水溶性差、生物利用率较低,其临床疗效还有待提升。因此,如何有效提升姜黄素的生物利用度与靶向性,使其更稳定地发挥治疗或保健功能,是目前研究者迫切需要解决的关键问题。通过对近年来姜黄素的相关文献资料进行归纳总结,对姜黄素的体内代谢途径进行概括,并对提高姜黄素疗效的相关策略及技术研究进行综述,为姜黄素的进一步研究和开发提供参考。Curcumin is a natural polyphenolic compound extracted from Curcuma longa,its medical value has been discovered for over 30 years.Curcumin could emerge great effect in anti-tumor,anti-inflammation,antioxidant,and other medical aspects in a small amount.Nevertheless,the therapeutical effect of curcumin remains to be improved due to the poor water solubility and low bioavailability.How to effectively improve the bioavailability and targeting of curcumin to meet the need of playing a more stable therapeutic or health function,is a key issue that researchers urgently need to solve.This article summarized the relevant literature on curcumin in recent years,combined with the in vivo metabolic process of curcumin,and reviewed the strategies and technologies on improving the therapeutical effect of curcumin,then providing reference for further research on the development of curcumin.

关 键 词：姜黄素 递药系统 纳米制剂 固相分散体 自微乳给药系统 前体药 姜黄素类似物 

分 类 号：R283[医药卫生—中药学]