中医药靶向调控线粒体质量控制系统治疗心肌缺血再灌注损伤研究进展  

Research progress on traditional Chinese medicine in treatment of myocardial ischemia reperfusion injury through targeted regulation of mitochondrial quality control system

作　　者：葛腾 齐鸿飞 姚彬 宁博 赵明君[1,3] GE Teng;QI Hongfei;YAO Bin;NING bo;ZHAO Mingjun(Shaanxi University of Chinese Medicine,Xianyang 712000,China;Shaanxi Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases,Xianyang 712000,China;Cardiovascular Division,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学,陕西咸阳712000 [2]陕西省中西医结合心血管病防治重点实验室,陕西咸阳712000 [3]陕西中医药大学附属医院心血管一科,陕西咸阳712000

出　　处：《中草药》2024年第15期5331-5341,共11页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划资助项目(2018YFC1704204);名中医赵明君传承工作室建设项目(2019007);陕西省教育厅重点实验室项目(22JS005);陕西省教育厅专项科研计划(21JK0606);咸阳市重点研发计划项目(L2023-ZDYF-SF-047)。

摘　　要：心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)是心梗后血流恢复再灌注诱发的一种疾病,以心肌细胞坏死、凋亡、线粒体功能障碍为主要病理特征,可能出现心肌顿抑、再灌注性心律失常和再发心绞痛等症状。线粒体是细胞代谢的基石,而线粒体质量控制系统(mitochondrial quality control,MQC)是线粒体内环境稳态的根基,也是反映线粒体质量的一个网络系统,对于监测和维持线粒体内环境稳态至关重要。而MQC紊乱可能导致MIRI。近年来,中医药疗法可通过多途径、多靶点、多层次显著改善MIRI。通过对中医药基于MQC治疗MIRI的研究进展进行梳理,为中医药治疗MIRI相关基础研究的转化以及拓展临床思路提供借鉴。Myocardial ischemia reperfusion injury(MIRI)is a disease induced by blood flow recovery and reperfusion after myocardial infarction,which is mainly characterized by myocardial cell necrosis,apoptosis and mitochondrial dysfunction.Symptoms such as myocardial stunning,reperfusion arrhythmias,and recurrent angina may occur.Mitochondria are the cornerstone of cell metabolism,and mitochondrial quality control(MQC)system is the foundation of mitochondrial homeostasis,is also a network system,reflect the quality of mitochondria and is vital for monitoring and maintenance of mitochondrial homeostasis.However,MQC disorder may lead to MIRI.In recent years,traditional Chinese medicine(TCM)therapy can significantly improve MIRI through multi-pathways,multi-targets and multi-levels.By summarizing the research progress of TCM therapy in the treatment of MIRI based on MQC,this study provides a reference for the transformation of basic research related to TCM therapy in the treatment of MIRI as well as the expansion of clinical thinking.

关 键 词：心肌缺血再灌注损伤 中医药 线粒体生物发生 线粒体动力学 线粒体自噬 线粒体氧化应激 线粒体蛋白稳态 线粒体凋亡 

分 类 号：R285[医药卫生—中药学]