川芎嗪注射液对急性缺血性脑梗死的治疗效果  

Therapeutic effect of ligustrazine injection on acute ischemic cerebral infarction

作　　者：李茂菁 吴鸿蔚 邓勋涛 吴跃明[4] Li Maojing;Wu Hongwei;Deng Xuntao;Wu Yueming(Graduate School,Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang 310053,China;Rehabilitation Medicine Department,Lishui People′s Hospital,Lishui,Zhejiang 323000,China;Department of Neurology,Li shui People′s Hospital,Lishui,Zhejiang 323000,China;Intensive Care Medicine Department,Lishui People′s Hospital,Lishui,Zhejiang 323000,China)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310053 [2]丽水市人民医院康复医学科,浙江丽水323000 [3]丽水市人民医院神经内科,浙江丽水323000 [4]丽水市人民医院重症医学科,浙江丽水323000

出　　处：《中国药物与临床》2024年第17期1117-1120,共4页Chinese Remedies & Clinics

摘　　要：目的探究川芎嗪注射液对急性缺血性脑梗死(中风-中经络)的治疗效果。方法将125例急性缺血性脑梗死(中风-中经络)患者分为对照组63例,试验组62例。对照组行常规基础药物治疗,试验组在对照组药物治疗基础上加用川芎嗪注射液治疗。比较治疗后2组治疗总体有效率、血清炎性因子肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)、神经元特异性烯醇化酶(NSE)水平以及血液黏度指标血浆黏度(PSV)、全血浆高切黏度(HSV)、全血浆低切黏度(LSV)水平。结果治疗后,试验组总有效率87.1%(54/62)高于对照组71.4%(45/63),差异有统计学意义(P<0.05);2组血清炎性因子TNF-α、CRP、NSE水平低于治疗前,差异有统计学意义(P<0.05);试验组降低水平高于对照组,差异有统计学意义(P<0.05);2组血液黏度指标PSV、HSV、LSV水平低于治疗前,差异有统计学意义(P<0.05),试验组降低水平高于对照组,差异有统计学意义(P<0.05)。2组治疗后的不良反应,差异无统计学意义(P>0.05)。结论川芎嗪注射液可以提高急性缺血性脑梗死(中风-中经络)的治疗总体有效率,降低血清炎性因子水平并减轻血液黏度促进血液运行。Objective To explore the therapeutic effect of ligustrazine injection on acute ischemic cerebral infarction(stroke-meridian).Methods A total of 125 patients with acute ischemic cerebral infarction(stroke meridian)were randomly divided into a control group(63 cases)and an study group(62 cases).The control group received conventional basic drug treatment,while the study group received treatment with ligustrazine injection in addition to conventional basic drug treatment.After treatment,the overall effective rate,serum inflammatory factors TNF-α,CRP,and NSE levels,as well as blood viscosity indicators PSV,HSV,and LSV levels were compared between the two groups.Results After treatment,the total effective rate of the study group(87.1%,54/62)was significantly higher than that of the control group(71.4%,45/63),and the difference was statistically significant(P<0.05).The levels of serum inflammatory factors TNF-α,CRP,and NSE in both groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).Moreover,the degree of reduction in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of blood viscosity indicators PSV,HSV,and LSV in both groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).Furthermore,the degree of reduction in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups after treatment(P>0.05).Conclusion Ligustrazine injection can improve the overall treatment efficiency of acute ischemic cerebral infarction(stroke-meridian),reduce the level of serum inflammatory factors,and reduce blood viscosity to promote blood circulation.

关 键 词：川芎嗪注射液 脑梗死 血液黏度 治疗结果 炎性因子 

分 类 号：R277.7[医药卫生—中医学]