新型动物专用大环内酯类抗生素泰地罗新的合成  

Synthesis of a Novel Macrolide Antibiotic Tildipirosin for Animals

作　　者：邓玉晓 马居良 孔祥雨 闫磊 刘葵葵 李欣 孙晋瑞 徐令文 张彬 李新志 刘文涛 DENG Yu-xiao;MA Ju-liang;KONG Xiang-yu;YAN Lei;LIU Kui-kui;LI Xin;SUN Jin-rui;XU Ling-wen;ZHANG Bin;LI Xin-zhi;LIU Wen-tao(Shandong Academy of Pharmaceutical Science,Ji'nan 250101,China;Jinan Jiulong Pharmaceutical Technology Co.,Ltd.,Ji'nan 250101,China)

机构地区：[1]山东省药学科学院,山东济南250101 [2]济南久隆医药科技有限公司,山东济南250101

出　　处：《精细化工中间体》2024年第4期17-21,共5页Fine Chemical Intermediates

基　　金：山东省科技型中小企业创新能力提升项目(2023TSGC0110)。

摘　　要：以泰乐菌素为起始物料,经还原胺化、水解、碘代、取代反应合成泰地罗新,纯度99.7%(HPLC),总收率60.1%,产物结构经质谱、~1HNMR和^(13)CNMR谱确证。该合成方法“三废”少,反应条件温和,工艺操作简单,具有工业化应用前景。The target compound Tildipirosin in purity of 99.7%(HPLC)and overall yield of 60.1%was synthesized by Reductive amination,hydrolytic reaction,Iodization reaction,N-alkylation reaction from Tylosin,and the structure of the product was characterized by'H NMR,13C NMR.The advantages of this procedure include less pollution,mild reaction condition and easy operation.Therefore it has a promising future in industrial application.

关 键 词：泰地罗新 泰乐菌素 固体酸 

分 类 号：TQ460.6[化学工程—制药化工]