盐酸头孢吡肟精氨酸混粉工艺研究  

Study on the Mixing Process of Cefepime Hydrochloride and Arginine Powder

作　　者：田洪年 申新辉 孙志远 梁丙辰 胡利敏 姜鹏鹏 TIAN Hong-nian;SHEN Xin-hui;SUN Zhi-yuan;LIANG Bing-chen;HU Li-min;JIANG Peng-peng(Hebei Hejia Pharmaceutical Group Co.,Ltd.,Shijiazhuang 052165,China;Hebei Hejia Pharmaceutical Group Co.,Ltd.,Hejia Research Institute,Shijiazhuang 052165,China)

机构地区：[1]河北合佳医药科技集团股份有限公司,河北石家庄052165 [2]河北合佳医药科技集团合佳研究院,河北石家庄052165

出　　处：《精细化工中间体》2024年第4期22-26,33,共6页Fine Chemical Intermediates

摘　　要：以结晶温度、磨网孔径、混粉比例等条件为考察因素,盐酸头孢吡肟粒度为考察指标,优化了盐酸头孢吡肟精氨酸混粉工艺。优化的混粉工艺为:结晶温度9.0℃、磨网孔径1.0mm、混粉比例1∶0.590、混粉转速8.1r/min、混粉时间45min、震荡强度65%。所得产品易于制剂分装,适用于工业化生产。The aim of the study is to optimize the mixing process of cefepime hydrochloride arginine powder.Using conditions such as crystallization temperature,mesh size,and mixing ratio as examination factors,and the particle size of cefepime hydrochloride as examination indicators,explore the optimal mixing conditions.The optimal mixing process is determined as follows:crystallization temperature of 9.0 C,grinding mesh aperture of 1.0 mm,mixing ratio of 1:0.590,mixing speed of 8.1 r/min,mixing time of 45 minutes,and vibration strength of 65%.The product obtained by this process is easy to package and suitable for industrial production.

关 键 词：盐酸头孢吡肟 精氨酸 混粉 正交试验 响应面 

分 类 号：R978.1[医药卫生—药品] TQ450.6[医药卫生—药学]