原子吸收分光光度法测定注射用头孢唑林钠中钠含量  

Analysis of Sodium Content in Cefazolin Sodium for Injection

作　　者：谷艺凡 表亚囡 于晓娜 刘莹 焦云飞 GU Yi-fan;BIAO Ya-nan;YU Xiao-na;LIU Ying;JIAO Yun-fei(Huabei Pharmaceutical Hebei Huamin Pharmaceutical Co.,Ltd.,Hebei Province Cephalosporide Medicine Preparation Technology,Shijiazhuang 052165,China)

机构地区：[1]华北制药河北华民药业有限责任公司河北省头孢类药物制备技术创新中心,河北石家庄052165

出　　处：《精细化工中间体》2024年第4期90-93,共4页Fine Chemical Intermediates

摘　　要：采用原子吸收分光光度法测定注射用头孢唑林钠中钠的含量。光源为钠空心阴极灯,空气-乙炔火焰原子化器,波长330.2nm。该方法的检测限为0.09%,定量限为0.31%,系统精密度RSD为0.68%(n=6),重复性RSD为0.62%,中间精密度RSD为1.49%,线性范围为0.2003~0.4007mg/m L(r=0.999),平均回收率为100.8%(RSD为0.91%)。该方法专属性、精密度、线性、耐用性等参数符合要求,可用于测定注射用头孢唑林钠中钠的含量,准确度和灵敏度高。The research is dedicated to determining the content of sodium in cefazolin sodium for injection by atomic absorption spectrophotometry.Atomic absorption spectrophotometry was used,the light source was a sodium hollow cathode lamp,the atomizer was an air-acetylene flame atomizer,and the wavelength was 330.2 nm.The detection limit of this method was 0.09%,the quantitative limit was 0.31%,the system precision RSD was 0.68%(n=6),the repeatable RSD was 0.62%,the intermediate precision RSD was 1.49%,and the linear range was 0.2003~0.4007 mg/mL(r=0.999).The average recovery rate was 100.8%(RSD was 0.91%).The specificity,precision,linearity and durability of this method meet relevant requirements.This method can be used to determine the content of sodium in cefazolin sodium for injection with high accuracy and sensitivity.

关 键 词：钠含量 注射用头孢唑林钠 原子吸收分光光度法 方法学验证 

分 类 号：R927.2[医药卫生—药学] TQ460.7[化学工程—制药化工]