负载生长因子的微纳米纤维创面敷料的制备与应用研究进展  

Progress in peparation and application of micro-nanofiber wound dressings loaded with growth factors

作　　者：蔺志浩 房磊 贾娇娇 扈延龄[1] 房宽峻[3,4,5,6] LIN Zhihao;FANG Lei;JIA Jiaojiao;HU Yanling;FANG Kuanjun(Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China;School of Textile Science and Engineering,Tiangong University,Tianjin 300387,China;College of Textiles and Clothing,Qingdao University,Qingdao,Shandong 266071,China;Collaborative Innovation Center for Eco-Textiles of Shandong Province and the Ministry of Education,Qingdao,Shandong 266071,China;Supported by State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao,Shandong 266071,China;Shandong Provincial Key Laboratory of Medical and Health Textile Materials,Qingdao,Shandong 266071,China)

机构地区：[1]青岛大学附属医院,山东青岛266000 [2]天津工业大学纺织科学与工程学院,天津300387 [3]青岛大学纺织服装学院,山东青岛266071 [4]生态纺织省部共建协同创新中心,山东青岛266071 [5]生物多糖纤维成形与生态纺织省部共建国家重点实验室,山东青岛266071 [6]山东省医疗健康纺织材料重点实验室,山东青岛266071

出　　处：《纺织学报》2024年第9期244-251,共8页Journal of Textile Research

基　　金：山东省重点研发计划项目(2023CXPT022);山东省科技型中小企业创新能力提升工程项目(2021TSGC1189)。

摘　　要：伤口愈合是一个动态的、复杂的、多细胞参与的过程,理想的创面修复材料对促进伤口的愈合至关重要,为实现更好的创面愈合,可在创面修复材料中添加生长因子等物质。首先总结了碱性成纤维细胞生长因子、表皮生长因子、血小板衍生生长因子这3种生长因子的作用及其在创面愈合过程中的作用环节及机制,阐述了微纳米纤维支架、微球和纳米颗粒等生长因子的可控释放递送策略,重点讨论了负载一种或多种生长因子的微纳米纤维创面敷料。研究指出,生长因子的作用已被广泛证实,不同的生长因子参与伤口愈合的不同阶段,微纳米纤维作为一种可控释放的递送系统及理想的创面修复材料,在皮肤创面愈合医用敷料领域拥有广泛的应用前景。Significance Wound healing is a dynamic,complex and multicellular process.The healing process of skin involves four distinct stages:hemostasis,inflammation,proliferation,and tissue remodeling.Although the skin has the ability to regenerate itself,certain types of wounds such as extensive injuries or chronic wounds are difficult to self-heal,so it is very important to develop wound dressings that promote self-healing.Micro-nanofibers have a high surface area-to-volume ratio area and high porosity,and have a similar structure to extracellular matrix,which is conducive to cell adhesion and proliferation,thus promoting wound healing.Growth factor is a signaling protein that regulates cell growth,differentiation,proliferation,migration and metabolism during different wound healing processes.The use of growth factors and their combination on the basis of the dressing is considered to be a promising treatment method to promote active healing.Progress Firstly,the three growth factors and their functions are summarized.At present,the most studied growth factors are basic fibroblast growth factor,epidermal growth factor and platelet-derived growth factor.Growth factors are involved in the four stages of skin wound healing.Growth factors play a key role in granulation tissue formation,regulating inflammatory response,and promoting angiogenesis.In addition,growth factors can also promote the proliferation and migration of wound cells to accelerate or improve the wound healing process.Secondly,growth factor delivery strategies are explored.In order to avoid degradation or inactivation of growth factors at the wound site and to maintain their continuous release at the wound site,a large number of studies have explored the effective loading mode of growth factors and developed excellent growth factor delivery systems.These methods include micro-nanofiber scaffolds,microspheres combined with nanoparticles and heparin,which avoid the burst release of growth factors and are conducive to its long-term effect.Finally,the micro/nanof

关 键 词：生长因子 微纳米纤维 医用敷料 碱性成纤维细胞生长因子 表皮生长因子 血小板衍生生长因子 

分 类 号：TQ342[化学工程—化纤工业] R318.08[医药卫生—生物医学工程]