布地格福联合K5压力阈值吸气肌训练对AECOPD患者呼吸力学参数及生命质量的影响  

Effects of budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with K5 pressure threshold inspiratory muscle training on respiratory mechanics parameters and quality of life in patients with AECOPD

作　　者：黄玉梅 龚享文 李志腾 Huang Yu-mei;Gong Xiang-wen;Li Zhi-teng(Department of Respiratory and Critical Care Medicine,Ganzhou Key Laboratory of Respiratory Diseases,Ganzhou Fifth People's Hospital,Ganzhou Research Institute of Respiratory Disease Prevention and Control,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市第五人民医院(赣州市呼吸疾病重点实验室,赣州市呼吸病防治研究所)呼吸与危重症医学科,江西赣州341000

出　　处：《四川生理科学杂志》2024年第9期1902-1904,2081,共4页

基　　金：赣州市卫生健康委员会市级科研计划项目(编号:2022-2-125)。

摘　　要：目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的80例慢阻肺急性加重期患者作为研究对象,按照随机数字表分为对照组和观察组,各40例。对照组使用布地格福进行治疗,观察组在对照组的基础上联合K5压力阈值吸气肌训练治疗,两组均治疗30d。分别比较患者治疗前后的圣乔治评分(St.George's Respiratory Questionnaire,SGRQ)、6分钟步行试验(6-minute walk test,6MWT)、最大吸气压(Maximum inspiratory pressure,MIP),并通过测量第1秒呼气量(Forced Expiratory Volume in the first second,FEV1)、用力肺活量(Forced Vital Capacity,FVC)、弥散功能血氧饱和度(Oxygen saturation of blood,SaO_(2))、动脉氧分压(Arterial Oxygen Partial Pressure,PO_(2))、动脉二氧化碳分压(Partial pressure of arterial carbon dioxide,PCO_(2))对肺功能和血气指标进行比较分析,对其进行比较分析。结果:观察组的SGRQ三项评分均低于对照组(P<0.05);治疗后观察组的6MWT和MIP两项都比对照组高(P<0.05);观察组的FEV1、FVC和弥散功能三项指标都高于对照组(P<0.05);观察组的SaO_(2)和PO_(2)明显高于对照组,PCO_(2)明显低于对照组(P<0.05)。结论:布地格福吸入气雾剂联合K5压力阈值吸气肌训练能有效减轻患者的症状,改善呼吸力学参数并提高生命质量,延长患者生存时间。Objective:To study the effects of budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with K5 pressure threshold inspiratory muscle training on respiratory mechanics parameters and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 80 patients with AECOPD treated in Ganzhou Fifth People's Hospital were enrolled and randomly divided into control group(n=40,budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol)and observation group(n=40,K5 pressure threshold inspiratory muscle training on basis of control group)between January 2022 and January 2024.All patients were treated for 30d.The scores of St.George's respiratory questionnaire(SGRQ)and 6-minute walking test(6MWT),maximum inspiratory pressure(MIP)were compared before and after treatment.The lung function and blood gas indexes were compared by forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),oxygen saturation of blood(SaO_(2)),partial pressure of arterial oxygen(PO_(2))and partial pressure of arterial carbon dioxide(PCO_(2)).Results:SGRQ scores in observation group were lower than those in control group(P<0.05).After treatment,6MWT score and MIP in observation group were higher than those in control group(P<0.05).FEV1,FVC and diffusion function in observation group were higher than those in control group(P<0.05).SaO_(2) and PO_(2) in observation group were significantly higher than those in control group,while PCO_(2) was significantly lower than that in control group(P<0.05).Conclusion:Budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with K5 pressure threshold inspiratory muscle training can effectively relieve symptoms,improve respiratory mechanics parameters and quality of life,and prolong survival in patients.

关 键 词：布地格福 K5压力阈值吸气肌训练 AECOPD 生命质量 呼吸功能 

分 类 号：R563.9[医药卫生—呼吸系统]