血清TC、HDL-C表达水平与ST段抬高型心肌梗死患者冠脉病变程度的相关性分析  

Correlation analysis of serum TC and HDL-C expression levels with the degree of coronary artery lesions in patients with ST segment elevation myocardial infarction

作　　者：李政阳 Li Zheng-yang(Department of Clinical Laboratory,Center Hospital of Shangqiu,Shangqiu 476000,Henan,China)

机构地区：[1]河南省商丘市中心医院检验科,河南商丘476000

出　　处：《四川生理科学杂志》2024年第9期2035-2037,2121,共4页

摘　　要：目的:探讨ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者血清总胆固醇(Total cholesterol,TC)、高密度脂蛋白胆固醇(High-Density lipoprotein cholesterol,HDL-C)表达及与冠脉病变程度的关系。方法:选取2019年1月至2023年5月于本院体检的75例健康者资料,纳入对照组;选取同期于本院就诊的75例SREMI患者资料,纳入观察组。回顾分析TC、HDL-C水平。分析STEMI患者冠脉病变程度,并根据冠脉病变程度将患者分为轻度组(24例)与重度组(51例)。分析比较两组基线资料。探讨血清TC、HDL-C与STEMI患者冠脉病变程度的关系。结果:相较于对照组,观察组的TC显著提高、HDL-C显著降低(P<0.05)。轻度组与重度组在性别、年龄段、体质量指数、基础疾病等方面均无显著差异(P>0.05)。相较于轻度组,重度组的Hcy、TC均显著提高,HDL-C显著降低(P<0.05)。Logistic回归分析结果显示:STEMI患者冠脉病变程度可能与Hcy高表达、TC高表达、HDL-C低表达有关(P<0.05)。TC高表达、HDL-C低表达时STEMI患者冠脉重度病变风险是TC低表达、HDL-C高表达时的43.646倍,协同效应为二者单独存在产生效应之和的3.553倍(交互作用指数(The synergy index,SI)=3.553)。结论:TC高表达、HDL-C低表达可能是STEMI患者的冠脉重度病变的危险因素。Objective:Study on ST-segment elevation myocardial infarction(ST-segment elevation myocardial infarction,ST-segment elevation myocardial infarction,ST-segment elevation myocardial infarction,ST-segment elevation myocardial infarction,The expression of serum Total cholesterol(TC)and High Density lipoprotein cholesterol(HDL-C)in patients with STEMI and their relationship with the degree of coronary artery disease.Methods:Data of 75 healthy subjects who underwent physical examination in our hospital from January 2019 to May 2023 were selected and included in the control group.Data of 75 SREMI patients treated in our hospital during the same period were selected and included in the observation group.The levels of TC and HDL-C were detected.STEMI patients were divided into mild group(24 cases)and severe group(51 cases)according to the degree of coronary artery disease.The baseline data of the two groups were analyzed and compared.To investigate the relationship between serum TC,HDL-C and the degree of coronary artery disease in STEMI patients.Results:Compared with the control group,TC in observation group was significantly increased and HDL-C was significantly decreased(P<0.05).There were no significant differences in gender,age,body mass index and underlying diseases between mild group and severe group(P>0.05).Compared with mild group,Hcy and TC in severe group were significantly increased,and HDL-C was significantly decreased(P<0.05).Logistic regression analysis showed that the degree of coronary lesions in STEMI patients may be related to the high expression of Hcy,the high expression of TC and the low expression of HDL-C(P<0.05).The risk of severe coronary lesions in STEMI patients with high TC expression and low HDL-C expression was 43.646 times higher than that with low TC expression and high HDL-C expression,and the synergistic effect was 3.553 times greater than the sum of the two effects alone(SI=3.553).Conclusion:High expression of TC and low expression of HDL-C may be risk factors for severe coronary artery

关 键 词：ST段抬高型心肌梗死 总胆固醇 高密度脂蛋白胆固醇 冠脉病变程度 

分 类 号：R542.22[医药卫生—心血管疾病]