Measures of insulin resistance and beta cell function before and after treatment of HCV infection  

作　　者：Jizheng Chen Pan Qiu Tingfeng Zhao Haowei Jiang Kebinur Tursun Sulaiman Ksimu Xinwen Chen Qian Wang 

机构地区：[1]State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510182,China [2]Jiangsu Province Key Lab of Human Functional Genomics,Department of Biochemistry and Molecular Biology,Nanjing Medical University,Nanjing,210029,China [3]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,430071,China [4]Guangzhou Laboratory,Guangzhou,510005,China [5]The First Affiliated Hospital of Xinjiang Medical University,Urumchi,830054,China

出　　处：《Virologica Sinica》2024年第4期667-674,共8页中国病毒学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(grant number 82170838,82370873);Open Research Fund Program of the State Key Laboratory of Virology of China(grant number 2018IOV003).

摘　　要：The association between chronic HCV infection and type 2 diabetes mellitus(T2DM)has been established;however,there is limited research onβ-cell function particularly in the pre-diabetic population.Here,we evaluated indices ofβ-cell function and insulin sensitivity across the spectrum from normal glucose tolerance to T2DMin individuals with and without chronic hepatitis C(CHC),and the effects of antiviral treatments on these variables.A total of 153 noncirrhotic,non-fibrotic CHC patients with a BMI<25 were enrolled in the study.Among them,119 were successfully treated with either direct acting antiviral(DAA)drugs or pegylated interferon/ribavirin(IFN/RBV)anti-HCV therapy.Fasting state-and oral glucose tolerance test(OGTT)-derived indexes were used to evaluateβ-cell function and insulin sensitivity.Among all subjects,19(13%)had T2DM and 21%exhibited pre-diabetes including 8%isolated impaired fasting glucose(IFG)and 13%combined IFG and impaired glucose tolerance(IGT).Early and total insulin secretion adjusted for the degree of insulin resistance were decreased in pre-diabetic CHC patients compared to HCVuninfected individuals.Viral eradication through DAA or IFN/RBV therapy demonstrated positive impacts on insulin sensitivity andβ-cell function in CHC patients who achieved sustained virologic response(SVR),regardless of fasting or OGTT state.These findings emphasize the role of HCV in the development ofβ-cell dysfunction,while also suggesting that viral eradication can improve insulin secretion,reverse insulin resistance,and ameliorate glycemic control.These results have important implications for managing pre-diabetic CHC patients and could prevent diabetes-related clinical manifestations and complications.

关 键 词：Hepatitis C virus(HCV) Type 2 diabetes(T2DM) Beta cell(β-cell) Insulin secretion 

分 类 号：R512.63[医药卫生—内科学]