Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection  

作　　者：Jinzhu Feng Zeyu Pu Rong Li Yuzhuang Li Xuewen Qin Hui Zhang Yiwen Zhang 

机构地区：[1]Institute of Human Virology,Department of Pathogen Biology and Biosecurity,Key Laboratory of Tropical Disease Control of Ministry of Education,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,510080,China

出　　处：《Virologica Sinica》2024年第4期699-701,共3页中国病毒学（英文版）

基　　金：supported by the National Key R&D Program of Department of Science and Technology of China(2022YFC0870700);the Important Key Program of Natural Science Foundation of China(NSFC)(92169201);the Exchange Program of NSFC(82150710553);the Emergency Key Program of Guangzhou National Laboratory(EKPG21-24);the Key R&D Program of Department of Science and Technology of Guangdong(2022B1111020004)to H.Z.Natural Science Foundation of China(92169108 and 32000613);Guangdong Natural Science Funds for Distinguished Young Scholar(2023B1515020005)to Y.Z.

摘　　要：Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required for comprehending the transmission dynamics of COVID-19(Bobrovitz et al.,2023).Additionally,current SARS-CoV-2 variants cause widespread escape from the neutralizing antibody(nAb)elicited by current vaccines.Meanwhile,durable neutralization and memory B cell responses can be predicted by rapid CD4t T cell responses,particularly strong circulating T follicular helper(cTfh)cell responses,in individuals infected with SARS-CoV-2(Gong et al.,2020;Boppana et al.,2021;Narowski et al.,2022).Although nAb titers are known as predictors of protection against SARS-CoV-2 variants(Khoury et al.,2021),identifying more potential factors that could predict the risk of re-infection following primary infection and vaccination has become quite important in shaping prevention strategies(Chemaitelly et al.,2023).

关 键 词：INFECTION prevention subsequent 

分 类 号：R563.1[医药卫生—呼吸系统]