Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual  

作　　者：Jie-Mei Yu Ze-Yin Liang Yuan-Hui Fu Xiang-Lei Peng Yan-Peng Zheng Yu-Jun Dong Jin-Sheng He 

机构地区：[1]College of Life Sciences and Bioengineering,Beijing Jiaotong University,Beijing,100044,China [2]Department of Hematology,Peking University First Hospital,Beijing,100034,China

出　　处：《Virologica Sinica》2024年第4期705-707,共3页中国病毒学（英文版）

基　　金：supported by the Natural Science Foundation of Beijing Municipality(L222074);Key R&D Program of Shandong Province,China(2019JZZY011011).

摘　　要：Dear Editor,Patients undergoing allogeneic hematopoietic stem cell transplantation(HSCT)often experience a significant reduction in immune function due to factors such as severe lymphopenia,immunosuppressive treatment,and the development of graft-versus-host disease,rendering them more susceptible to severe infections(Sahin et al.,2016).Traditional diagnostic approaches are limited in sensitivity,speed,and assay targets,thus failing short of meeting the diagnostic demands(Qu et al.,2022).However,next-generation sequencing(NGS)has greatly improved the accuracy and efficiency of diagnosing various diseases(Schuler et al.,2022),and has been widely utilized for pathogen detection in samples from HSCT patients(Armstrong et al.,2019;Peng et al.,2021).In this study,we employed viral metagenomics analysis using high-throughput sequencing on fecal and tissue samples from a patient with HSCT experiencing severe lingual papillomatosis.

关 键 词：al. PAPILLOMA rendering 

分 类 号：R511.8[医药卫生—内科学]