对二羟基苯丙氨酸硼-硼中子俘获治疗临床应用进展  

Advances of clinical application of BPA-BNCT

作　　者：韩青青 杨乔 李拓 霍力[1,2] Han Qingqing;Yang Qiao;Li Tuo;Huo Li(Department of Nuclear Medicine,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院核医学科,北京100730 [2]核医学分子靶向诊疗北京市重点实验室,北京100730

出　　处：《中国医学装备》2024年第9期162-167,共6页China Medical Equipment

摘　　要：硼中子俘获治疗(BNCT)是一种基于核俘获和核裂变反应的放射治疗模式。对二羟基苯丙氨酸硼(BPA)是BNCT中应用最广泛的肿瘤细胞选择性载硼药物。当前,国内外开展多项BPA-BNCT治疗脑肿瘤、黑色素瘤及头颈部肿瘤等多种肿瘤的临床试验,其有效性已得到一定程度的证实。为提高BPA-BNCT疗效,多项研究探索了BPA联合其他载硼药物、BPA-BNCT联合化疗药物或BPA-BNCT联合放射治疗的多种治疗模式,但上述治疗模式对肿瘤患者的预后改善能力仍存疑。目前BPA-BNCT发展受到载硼药物及中子设备等方面的限制,但随着第三代载硼药物的开发及加速器BNCT(ABBNCT)的建设成功,BNCT的应用前景十分广阔。综述BPA-BNCT在多种恶性肿瘤的临床研究的新进展,探讨BNCT临床研究面临的机遇与挑战。Boron neutron capture therapy(BNCT)is a radiotherapy modality based on nuclear capture and nuclear fission reactions.Boronophenylalanine(BPA)is a most widely tumor cell-selective boron carrier drug in the application of BNCT.Currently,many BPA-BNCT clinical trials have been conducted in treating brain tumors,melanoma,and head and neck tumors,which effectiveness has been confirmed to a certain extent.In order to improve the curative efficacy of BPA-BNCT,a number of studies have explored many kinds of treatment modalities included the combination of BPA and other boron-carrying drugs,the combination of BPA-BNCT and chemotherapeutic agents or the combination of BPA-BNCT and radiation therapy,but it is still questionable in terms of the prognostic improvement ability of the above treatment modalities on patients with tumors.At present,the development of BPA-BNCT is limited by boron-carrying drugs and neutron equipment,but the applied prospect of BNCT is very broad with the development of the third-generation boron-carrying drugs and the success of the construction of accelerator-based BNCT(AB-BNCT).This paper reviewed the new progress of BPA-BNCT in clinical research for multiple malignant tumors,and explored the facing opportunities and challenges of BNCT in clinical research.

关 键 词：硼中子俘获治疗(BNCT) 对二羟基苯丙氨酸硼(BPA) 脑肿瘤 黑色素瘤 

分 类 号：R815[医药卫生—放射医学]