基于数据挖掘探讨中医药在辅助生殖技术中的分期应用  

The Phased Application of Traditional Chinese Medicine in Assisted Reproductive Technology:A Data Mining

作　　者：宫政 王聪[1] 宋佳怡 夏天[1] GONG Zheng;WANG Cong;SONG Jia-yi;XIA Tian(Department of Reproductive Medicine,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Reproductive Medicine Center,First Affiliated Hospital of Ningbo University,Ningbo 315012,Zhejiang Province,China)

机构地区：[1]天津中医药大学第一附属医院/国家中医针灸临床医学研究中心生殖医学科,300381 [2]宁波大学附属第一医院生殖医学中心

出　　处：《国际生殖健康／计划生育杂志》2024年第5期361-367,共7页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(82274570)。

摘　　要：目的:基于数据挖掘技术整合分析名医名家临证应用中医药配合辅助生殖技术(assisted reproductive technology,ART)的各期方药分布规律。方法:计算机系统检索中国知网、维普中文科技期刊数据库、万方数据库和中国生物医学文献数据库中名医名家临证应用中医药配合ART的相关文献,建立文献分析数据库进行整合归纳,获得其中药物分布规律。结果:本研究纳入合格文献共112篇,涉及名家36人。降调期药物共获得总类别13种,相关药物77味,累计出现频次224次,频率较高者为“补虚药”(55.94%)、“活血化瘀药”(10.89%)、“清热药”(6.44%)、“收涩药”(5.45%)、“利水渗湿药”(5.45%)等;促排期药物共获得总类别13种,相关药物92味,累计出现频次398次,频率较高者为“补虚药”(61.34%)、“活血化瘀药”(8.68%)、“收涩药”(8.40%)、“清热药”(5.88%)、“利水渗湿药”(5.32%)等;移植期药物共获得总类别14种,相关药物70味,累计出现频次372次,频率较高者为“补虚药”(68.78%)、“祛风湿药”(5.80%)、“活血化瘀药”(5.52%)等;确认妊娠后用药物共获得总类别11种,相关药物47味,累计出现频次182次,频率较高者为“补虚药”(59.88%)、“祛风湿药”(9.30%)、“清热药”(7.56%)、“收涩药”(5.23%)等。四期用药关联分析显示降调期分析得18组药物组合,促排期分析得14组药物组合,移植期分析得41组药物组合,确认妊娠后分析得22组药物组合。四期用药聚类分析结果显示降调期得到核心药物组:党参-甘草-白术-黄芪-酸枣仁、菟丝子-枸杞子-熟地黄-当归-香附、熟地黄-白芍-阿胶-菟丝子-生地黄;促排期得到核心药物组:菟丝子-熟地黄-山药-枸杞子-桑椹、菟丝子-熟地黄-当归-枸杞子-丹参、熟地黄-山茱萸-山药-菟丝子-生地黄;移植期得到核心药物组:白术-续断-桑寄生-党参-菟丝子、桑寄生-菟丝子-续断-黄芩-阿胶�Objective:To integrate and analyze the application of traditional Chinese medicine(TCM)with assisted reproductive technology(ART)at the different periods of the treatment from those famous TCM experts,based on a data mining.Methods:To search the related documents of the application of TCM and ART from famous TCM experts in the CNKI、CQVIP、Wanfang、CBM databases of Chinese.We aimed to establish a literature analysis database for the integration and induction to obtain the distribution of commonly used drugs.Results:This study included 112 qualified documents,involving 36 famous TCM experts.The total number of drugs in the down-regulation period was 13,with 77 flavors of related drugs and 224 cumulative frequencies of occurrence.The higher frequencies were 55.94%of"drugs for tonifying deficiency",10.89%of"drugs for activating blood circulation and removing blood stasis",6.44%of"heat-clearing drugs",5.45%of"astringent drugs",and 5.45%of"water-inducing and dampness-expelling drugs".In the ovulation promotion period,the total number of drugs was 13,with 92 flavors of related drugs and 398 cumulative frequencies of occurrence.In this period,the higher frequencies were of 61.34%of"drugs for tonifying deficiency",8.68%of"drugs for activating blood circulation and removing blood stasis",8.40%of"astringent drugs",5.88%of"heat-clearing drugs",5.32%of"water-inducing and dampness-expelling drugs",etc.In the transplantation period,the total number of drugs was 14,with 70 flavors of the relevant drugs and 372 cumulative frequencies.In the transplantation period,the higher frequencies were 68.78%of"drugs for tonifying deficiency",5.80%of"drugs for dispelling wind-dampness"and 5.52%of"drugs for activating blood circulation and removing blood stasis".The drugs used after pregnancy were confirmed to have a total of 11 categories,with 47 flavors and 182 cumulative frequencies.During pregnancy,the higher frequencies were 59.88%of"drugs for tonifying deficiency",9.30%of"drugs for dispelling wind-dampness",7.56%of"heat-clearing dru

关 键 词：生殖技术 辅助 中药 名家经验 中医药学文献 

分 类 号：R271.9[医药卫生—中西医结合]