核酸适配体生物传感器用于肝癌早期诊断的研究进展  

Research progress of nucleic acid aptamer biosensor for early diagnosis of liver cancer

作　　者：贾超凡 张凤娇 张璟[2] 闫业浩 魏胤 JIA Chao-fan;ZHANG Feng-jao;HANG Jing;YAN Ye-hao;WEI Yin(School of Public Health,Binzhou Medical University,Yantai 264000,China;School of Public Health,Jining Medical University,Jining 272000,China;School of Public Health,Shandong First Medical University,Jinan 250000,China)

机构地区：[1]滨州医学院公共卫生学院,山东烟台264000 [2]济宁医学院公共卫生学院,山东济宁272000 [3]山东第一医科大学公共卫生学院,山东济南250000

出　　处：《化学研究与应用》2024年第9期1968-1980,共13页Chemical Research and Application

基　　金：山东省自然科学基金青年项目(ZR2020QH297)资助。

摘　　要：甲胎蛋白和癌胚抗原作为肝癌的血清标志物,可用于肝癌的早期诊断。在本文中,描述了两种常见的基于核酸适配体的血清标志物检测方法,并对检测这两种标志物的光学生物传感器和电化学生物传感器的研究进展进行了综述。本文对这些生物传感器的性能进行了比较,为未来开发高灵敏度、高选择性的肝癌早期诊断新方法提供参考。Alpha-fetoprotein and carcinoembryonic antigen are used as serum markers for early diagnosis of hepatocellular carcinoma.In this paper,two common nucleic acid aptamer-based serum marker assays are described,and the research progress of optical and electrochemical biosensors for detecting these two markers is reviewed.The performance of these biosensors is compared in this paper to provide a reference for the future development of new methods for the early diagnosis of hepatocellular carcinoma with high sensitivity and high selectivity.

关 键 词：核酸适配体 生物传感器 甲胎蛋白 癌胚抗原 肝癌 

分 类 号：O652[理学—分析化学]