基于Fe-MIL-88B-NO_(2)/MWCNTs复合材料对芬太尼的电化学检测  

Electrochemical detection of fentanyl based on Fe-MIL-88B-NO_(2)/MWCNTs composites

作　　者：赵志东 何缘 祁星瑞 靳焘[1,2,4,6,7,8] ZHAO Zhi-dong;HE Yuan;QI Xing-rui;JIN Tao(Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Guangzhou 510650,China;University of Chinese Academy of Sciences,Beijing 100000,China;Guizhou Police College,Guiyang 550005,China;CAS Testing Technical Services(Guangzhou)Co.Ltd.,Guangzhou 510650,China;Guangdong Industry Polytechnic,Guangzhou 510300,China;CAS Engineering Laboratory for Special Fine Chemicals,Chinese Academy of Sciences,Guangzhou 510650,China;Guangdong Provincial Key Laboratory of Organic Polymer Materials for Electronics,Guangzhou 510650,China;West Center,Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Chongqing 400714,China)

机构地区：[1]中国科学院广州化学研究所,广东广州510650 [2]中国科学院,北京100000 [3]贵州警察学院,贵州贵阳550005 [4]中科院检测技术服务(广州)有限公司,广东广州510650 [5]广东轻工职业技术学院,广东广州510300 [6]中国科学院特种精细化学品工程实验室,广东广州510650 [7]国科广化韶关新材料研究院,广东广州510650 [8]国科广化(南雄)新材料研究院有限公司,广东广州512400

出　　处：《化学研究与应用》2024年第9期1997-2007,共11页Chemical Research and Application

基　　金：国家自然科学项目(42063002)资助;贵州省科技支撑计划项目(黔科合支撑[2023]一般441)资助。

摘　　要：芬太尼作为一种强效麻醉性阿片类镇痛药物,在临床手术被用作静脉麻醉的同时也被吸毒人员滥用,导致的死亡人数也逐年增多,因此急需开发一种对芬太尼的快速筛查方法。在此,我们向金属有机框架MIL-88B(Fe)中引人硝基修饰,通过调控MIL-88B(Fe)中Fe(I)周围的电子密度,调节其得失电子能力,增加MIL-88B(Fe)的活性位点,后与多壁碳纳米管(MWCNTs)超声复合修饰玻碳电极构建电化学传感器用于对芬太尼的检测。合成的MIL-88B-NO_(2)/MWCNTs复合材料修饰玻碳电极具有更低的电化学阻抗和更大的电化学表面积,对芬太尼的电化学检测表现出较高的灵敏度,得到检出限(LOD)为0.025μM,线性范围为0.08~10μM,重现性、选择性和稳定性均良好。此外,所开发的复合材料修饰电极在实际样品中表现良好,在0.2-1μM浓度下,在尿液和血液中的回收率分别为61.69%~80.35%和85.70%~93.06%。因此,所提出的MIL-88B-NO_(2)/MWCNTs复合材料可作为一种新型的电极修饰材料用作芬太尼的电化学传感器,在公安禁毒工作中对芬太尼的快速筛查具有很大的潜力。As a potent narcotic opioid analgesic,fentanyl has been used as intravenous anesthesia for clinical procedures while also being abused by drug users,resulting in an increasing number of deaths year by year,thus there is an urgent need to develop a rapid screening method for fentanyl.In this paper,a nitro modification was introduced into the metal-organic framework MIL-88B(Fe)to increase the active site of MIL-88B(Fe)by modulating the electron density around Fe(II)and regulating its ability of gaining and losing electrons,then the composites were obtained by ultrasonicated with multi-walled carbon nanotubes(MWCNTs)were used to modify glassy carbon electrodes(GCE)to construct electrochemical sensors for fentanyl detection.The synthesized MIL-88B-NO_(2)/MWCNTs composite modified GCE has lower electrochemical impedance and larger electrochemical surface area,and exhibits higher sensitivity to fentanyl,the limit of detection(LOD)was obtained to be 0.025μM,and the linear range was 0.08~10μM with favor-able reproducibility,selectivity and stability.In addition,the developed composite-modified electrodes showed satisfactory perform-ance in real samples,with recoveries of 61.69%~80.35%and 85.70%~93.06%in urine and blood,respectively,at concentrations of 0.2-1μM.Therefore,the proposed MIL-88B-NO,/MWCNTs composite can be used as a novel electrode modification material as an electrochemical sensor for fentanyl,which could have a great potential for rapid screening of fentanyl in public security anti-nar-coticswork.

关 键 词：芬太尼 MIL-88B-NO_(2) 多壁碳纳米管 差分脉冲伏安法 电化学检测 

分 类 号：O614.4[理学—无机化学]