三组分串联反应区域选择性合成双吲哚衍生物  

Three-component domino reactions for regioselective formation of bis-indoles

作　　者：王永辉[1] 杨德骏 WANG Yong-hui;YANG De-jun(The Education College,Chuzhou City Vocation College,Chuzhou 239000,China;Wenzhou Institute of Biomaterials and Engineering,Wenzhou Institute,UCAS,Wenzhou 325001,China)

机构地区：[1]滁州城市职业学院教育学院,安徽滁州239000 [2]中国科学院大学温州研究院,温州生物材料与工程研究所,浙江温州325001

出　　处：《化学研究与应用》2024年第9期2197-2202,共6页Chemical Research and Application

基　　金：安徽省教育厅省级质量工程项目(2020kfkc362;2021zyjxzyk024)资助;滁州城市职业学院平台项目(2023zkzd05)资助。

摘　　要：报道了一种微波辅助的区域选择性反应,该反应从芳酮醛水合物、N-芳基烯胺酮和吲哚出发,通过改变取代的吲哚底物来获得3,2′-和3,3′-双吲哚衍生物。该方法具有区域选择性高、反应时间短、操作简单等显著优点。A microwave-assisted regioselective reaction dealing with arylglyoxal monohydrate,diverse N-aryl enaminones,and indoles to achieve 3,2'-and 3,3'-bis-indoles by varying a substituted indole substrate was reported.The 2-unsubstituted indoles resulted in the 3,2'-bis-indole skeleton,whereas indoles bearing a methyl or phenyl group at C2 led to the 3,3'-bis-indoles with simultaneous formation of three sigma-bonds.The procedures featured excellent regioselectivity,short reaction times,convenient one-pot manner,and operational simplicity.

关 键 词：三组分串联反应 区域选择性 双吲哚衍生物 

分 类 号：O626[理学—有机化学]