^(131)I SPECT/CT在甲状腺癌术后随访中的应用价值  

Application value of ^(131)I SPECT/CT in postoperative follow-up of thyroid cancer

作　　者：何清 史育红 王朝点 HE Qing;SHI Yuhong;WANG Chaodian(Department of Nuclear Medicine,the Second Affiliated Hospital,Chengdu Medical College•416th Hospital of Nuclear Industry,Chengdu 610051)

机构地区：[1]成都医学院第二附属医院•核工业四一六医院核医学科,成都610051

出　　处：《郑州大学学报（医学版）》2024年第5期678-682,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：四川省医学科研课题计划项目(S18001)。

摘　　要：目的:探究^(131)I单光子发射CT/CT(SPECT/CT)在甲状腺癌术后随访中的应用价值。方法:选取2018年3月至2020年5月行全切术的分化型甲状腺癌患者122例,术后接受^(131)I治疗3 d,然后行^(131)I全身显像(^(131)I-WBS)和SPECT/CT,术后随访1 a,记录患者临床再分期、术后复发及转移情况。结果:术后临床再分期^(131)I-WBS判断正确率为75.4%(92/122),^(131)I SPECT/CT为91.8%(112/122),^(131)I SPECT/CT判断正确率高于^(131)I-WBS(P<0.001)。术后随访1 a,12例复发。^(131)I SPECT/CT高危显像对术后复发的检出率为12/12,高于^(131)I-WBS的7/12(P<0.001)。122例共526处^(131)I阳性摄取,其中347处转移。^(131)I SPECT/CT对转移灶诊断敏感度(98.6%vs 62.0%)、特异度(98.9%vs 85.5%)均高于^(131)I-WBS(P<0.001)。结论:^(131)I SPECT/CT可为甲状腺癌术后临床再分期及复发危险度分层提供更多准确信息,对转移灶具有较高的判断价值。Aim:To explore the application value of ^(131)I single-photon emission CT/CT(SPECT/CT)in postoperative follow-up of thyroid cancer.Methods:A total of 122 patients with differentiated thyroid cancer undergoing total resection between March 2018 and May 2020 were enrolled as the research objects,and all were treated with ^(131)I for 3 days after operation and then underwent ^(131)I whole-body scan(^(131)I-WBS)and SPECT/CT.All were followed up for 1 year,and the clinical restage,postoperative recurrence and metastasis were recorded.Results:In terms of postoperative clinical restaging,accuracy rate of ^(131)I SPECT/CT was higher than that of ^(131)I-WBS[91.8%(112/122)vs 75.4%(92/122),P<0.001].Twelve cases relapsed.Detection rate of postoperative recurrence by ^(131)I SPECT/CT was higher than that by ^(131)I-WBS(12/12 vs 7/12,P<0.001).In the 122 patients,there were 526^(131)I uptaking loci,in which 347 were metastases lesions.The sensitivity(98.6%vs 62.0%),specificity(98.9%vs 85.5%)of ^(131)I SPECT/CT were significantly higher than those of ^(131)I-WBS for the diagnosis of metastases(P<0.001).Conclusion:^(131)I SPECT/CT can provide more accurate information for postoperative clinical restaging and recurrence risk stratification of thyroid cancer,and has high diagnostic value for metastasis.

关 键 词：^(131)I SPECT/CT 甲状腺癌 术后随访 

分 类 号：R653[医药卫生—外科学]