穴位埋线配合中药治疗非酒精性单纯性脂肪肝的疗效观察  

Efficacy observation of catgut-embedding therapy plus Chinese herbal medicines in treating non-alcoholic simple fatty liver

作　　者：叶苗青 唐颖慧 刘皎皎 李粉萍 薛敬东 王红 何瑾瑜 YE Miaoqing;TANG Yinghui;LIU Jiaojiao;LI Fenping;XUE Jingdong;WANG Hong;HE Jinyu(Shaanxi Provincial Hospital of Chinese medicine,Xi’an 710003,China)

机构地区：[1]陕西省中医医院,西安710003

出　　处：《上海针灸杂志》2024年第9期993-998,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家中医优势专科(肝病)建设项目[国中医药办医政函(2024)90号];陕西省自然科学基金青年项目(2023-JC-QN-0977);西安市科技局科技计划项目(22YXYJ0115);宝鸡市卫健委科研计划项目(2023-047)

摘　　要：目的 观察穴位埋线配合泽茵丸治疗非酒精性单纯性脂肪肝的临床疗效。方法 将124例非酒精性单纯性脂肪肝患者随机分为治疗组和对照组,每组62例。对照组采用口服奥利司他胶囊治疗,治疗组在对照组基础上加用穴位埋线配合口服泽茵丸治疗。观察两组治疗前后各项中医证候评分、肝脾CT比值、受控衰减参数(controlled attenuation parameter, CAP)值、体质量、腹围、身体质量指数(body mass index, BMI)及各项实验室指标[血清丙氨酸氨基转移酶(alanine aminotransferase, ALT)、总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)水平]的变化情况,比较两组临床疗效。结果 治疗组治疗后愈显率为80.6%,明显高于对照组的54.8%(P<0.05)。两组治疗后各项中医证候评分、CAP值、体质量、腹围、BMI及TC、TG水平均较同组治疗前显著下降,肝脾CT比值均显著上升,差异均具有统计学意义(P<0.05)。治疗组治疗后部分中医证候评分(肝区不适或隐痛、形体肥胖、口苦评分及总分)、CAP值、体质量、腹围、BMI及TC、TG水平均明显低于对照组,肝脾CT比值明显高于对照组,差异均具有统计学意义(P<0.05)。结论 穴位埋线配合泽茵丸治疗非酒精性单纯性脂肪肝疗效确切,能显著升高肝脾CT比值,降低CAP值、体质量、腹围、BMI、TC、TG等指标。Objective To observe the clinical efficacy of catgut-embedding therapy plus Ze Yin pills in treating non-alcoholic simple fatty liver(NAFL).Method A total of 124 NAFL patients were randomized into a treatment group and a control group,with 62 cases in each group.The control group was given oral administration of Orlistat capsules,and the treatment group additionally received catgut-embedding therapy and oral Ze Yin pills.The symptom scores of traditional Chinese medicine(TCM),liver/spleen CT ratio,controlled attenuation parameter(CAP)value,body weight,abdominal circumference,body mass index(BMI),and laboratory indexes[alanine aminotransferase(ALT),total cholesterol(TC),and triglyceride(TG)]were observed before and after the treatment,and the clinical efficacy was compared between the two groups.Result The markedly effective rate was 80.6%in the treatment group,which was markedly higher than 54.8%in the control group(P<0.05).The TCM symptom score,CAP,body weight,abdominal circumference,BMI,and the levels of TC and TG dropped in both groups after the treatment,and the liver/spleen CT ratio increased,all showing statistical significance(P<0.05).After the intervention,a part of the TCM symptom scores(the scores of discomfort or dull pain in the liver region,an obese body,and bitter mouth,as well as the total score),CAP,body weight,abdominal circumference,BMI,and the TC and TG levels were lower in the treatment group than in the control group,and the liver/spleen CT ratio was higher in the treatment group;the differences were statistically significant(P<0.05).Conclusion Catgut-embedding therapy plus Ze Yin pills is effective in treating NAFL.This method can increase the liver/spleen CT ratio and lower indexes like CAP,body weight,abdominal circumference,BMI,TC,and TG.

关 键 词：穴位疗法 埋线 非酒精性单纯性脂肪肝 针药并用 受控衰减参数 

分 类 号：R246.1[医药卫生—针灸推拿学]