Protein-nucleic acid hybrid nanostructures for molecular diagnostic applications  

作　　者：Noah R.Sundah Yuxuan Seah Auginia Natalia Xiaoyan Chen Panida Cen Yu Liu Huilin Shao 

机构地区：[1]Institute for Health Innovation and Technology,National University of Singapore,Singapore 117599,Singapore [2]Department of Biomedical Engineering,College of Design and Engineering,National University of Singapore,Singapore 117583,Singapore [3]Integrative Sciences and Engineering Programme,NUS Graduate School,National University of Singapore,Singapore 119077,Singapore [4]Institute of Molecular and Cell Biology,Agency for Science,Technology and Research,Singapore 138673,Singapore [5]Department of Surgery,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 117597,Singapore

出　　处：《Nano Research》2024年第10期9003-9014,共12页纳米研究（英文版）

基　　金：supported in part by funding from National University of Singapore(NUS),NUS Research Scholarship,Ministry of Education,Institute for Health Innovation&Technology,Ministry of Education,National Research Foundation,and National Medical Research Council.

摘　　要：Molecular diagnostic technologies empower new clinical opportunities in precision medicine.However,existing approaches face limitations with respect to performance,operation and cost.Biological molecules including proteins and nucleic acids are being increasingly adopted as tools in the development of new molecular diagnostic technologies.In particular,leveraging their complementary properties—the functional diversity of proteins and the precision programmability of nucleic acids—a wide range of protein–nucleic acid hybrid nanostructures have been developed.These hybrid structures take diverse forms,ranging from one-dimensional to three-dimensional hybrids,as static assemblies to dynamic machines,and possess myriad functions to recognize target biomarkers,encode vast information and execute catalytic activities.Motivated by recent advances in this area of molecular nanotechnology,we review the state-of-art design and application of various types of protein–nucleic acid hybrid nanostructures for molecular diagnostics,and present an outlook on the challenges and opportunities for emerging pre-clinical and clinical applications,highlighting the promise for earlier detection,more refined diagnosis and highly tailored treatment decision that ultimately lead to improved patient outcomes.

关 键 词：molecular nanotechnology DNA-protein hybrid molecular diagnostics precision medicine 

分 类 号：TB383[一般工业技术—材料科学与工程]