慢性自发性荨麻疹患者的焦虑和抑郁水平评估  

Assessment of anxiety and depression in patients with chronic spontaneous urticaria

作　　者：黄雪梅[1] 欧珊珊 邹荟 林天一 吴伟鸿 陈紫嫣 李华平[1] 陈荃[1] 梁碧华[1] 朱慧兰[1] HUANG Xuemei;OU Shanshan;ZOU Hui;LIN Tianyi;WU Weihong;CHEN Ziyan;LI Huaping;CHEN Quan;LIANG Bihua;ZHU Huilan(Guangzhou Dermatology Hospital,Guangzhou Institute of Dermatology,Guangzhou 510095,China;Guangzhou Medical University,Guangzhou 511436,China)

机构地区：[1]广州市皮肤病医院广州市皮肤病防治所,广东广州510095 [2]广州医科大学,广东广州511436

出　　处：《皮肤性病诊疗学杂志》2024年第8期536-541,共6页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省自然科学基金(2019A1515011593);广州市科技计划项目(2023A03J0470)。

摘　　要：目的评估慢性自发性荨麻疹(CSU)患者的焦虑和抑郁水平,探讨焦虑、抑郁情绪评分与疾病活动度及生活质量之间的相关性。方法选择2023年8—12月在广州市皮肤病医院门诊治疗的CSU患者,采用问卷调查方式,收集患者临床资料及7日荨麻疹活动度评分(UAS7)、皮肤病生活质量指数(DLQI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分,对治疗达8周以上患者再次收集SAS、SDS评分。采用Pearson相关分析SAS、SDS评分与UAS7、DLQI的相关性,采用t检验比较治疗前后患者SAS、SDS评分的变化。结果共纳入CSU患者53例,其中15例(28.30%)存在焦虑问题,16例(30.19%)存在抑郁问题;焦虑状态患者的DLQI评分显著高于无焦虑状态患者(t=2.58,P=0.013),抑郁状态患者的UAS7评分显著高于无抑郁状态患者(t=2.29,P=0.026);Pearson相关分析示患者SAS评分与UAS7评分(r=0.31,P=0.029)、DLQI评分(r=0.33,P=0.020)存在正相关关系,而SDS评分与UAS7、DLQI评分无关(均P>0.05)。24例患者完成8周以上的治疗,与治疗前比较,治疗后SAS(t=3.97,P<0.001)、SDS(t=3.69,P=0.001)评分均显著下降。结论CSU患者常伴有焦虑/抑郁,生活质量越差者出现焦虑的可能性越大,疾病活动度越严重者出现抑郁的可能性越大。患者焦虑程度受疾病活动度及生活质量严重程度的影响。Objective To evaluate the severity of anxiety and depression in patients with chronic spontaneous urticaria(CSU)and explore the correlation between anxiety and depression scores,disease activity,and quality of life.Methods Outpatients with CSU were enrolled at Guangzhou Institute of Dermatology from August 2023 to December 2023.A questionnaire survey was used to collect clinical data and urticaria activity score 7(UAS7),dermatology life quality index(DLQI),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)from patients.SAS and SDS scores were obtained again after over 8-week treatments.Pearson correlation was used to analyze the correlation between SAS,SDS and UAS7 and DLQI.SAS and SDS were compared before and after the treatments.Results A total of 53 CSU patients were included,of which 15(28.30%)had anxiety and 16(30.19%)had depression.The DLQI score was significantly higher in CSU patients with anxiety than in those without anxiety(t=2.58,P=0.013),and the UAS7 score was significantly higher in patients with depression than in that without depression(t=2.29,P=0.026).Pearson correlation analysis showed a positive correlation of SAS with UAS7 and DLQI(r=0.31,P=0.029;r=0.33,P=0.020),while SDS was not related to UAS7 and DLQI(both P>0.05).After over 8-week treatments,SAS and SDS were significantly decreased in 24 patients(t=3.97,P<0.001;t=3.69,P=0.001).Conclusions CSU patients often have comorbidities of anxiety and depression.The poorer the quality of life,the greater the likelihood of anxiety,and the more severe the disease activity,the greater the likelihood of depression.Anxiety is correlated with disease activity and quality of life.

关 键 词：荨麻疹 慢性自发性 焦虑 抑郁 相关性分析 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]