经皮椎体成形术联合利塞膦酸钠治疗绝经后骨质疏松性椎体压缩骨折的疗效  

Efficacy of Percutaneous Vertebroplasty Combined with Risedronate Sodium in the Treatment of Postmenopausal Osteoporotic Vertebral Compression Fractures

作　　者：董玉池 刘剑[1] 张金玉[1] DONG Yuchi;LIU Jian;ZHANG Jinyu(Department of Spinal Trauma Surgery,Shouguang People's Hospital,Shouguang 262700,Shandong,China)

机构地区：[1]山东寿光市人民医院脊柱创伤外科,山东寿光262700

出　　处：《中外医疗》2024年第23期43-46,共4页China & Foreign Medical Treatment

摘　　要：目的分析对绝经后骨质疏松性椎体压缩骨折患者实施经皮椎体成形术联合利塞膦酸钠治疗的效果。方法便利选取2020年10月—2021年10月山东寿光市人民医院脊柱创伤外科收治的64例绝经后骨质疏松性椎体压缩骨折患者为研究对象,按照不同治疗方法分为比对组和研究组,每组32例。比对组行保守治疗,研究组实施经皮椎体成形术与利塞膦酸钠联合治疗,比较两组患者的治疗总有效率、椎体后凸Cobb角、不同治疗时间椎体高度压缩率、不良反应发生情况。结果研究组治疗总有效率为93.75%(30/32),高于比对组的81.25%(26/32),但差异无统计学意义(χ^(2)=1.286,P=0.257)。治疗15 d、治疗6个月时,研究组椎体后凸Cobb角均小于比对组,差异有统计学意义(P均<0.05)。治疗15 d、6个月时,研究组椎体高度压缩率均低于比对组,差异有统计学意义(P均<0.05)。研究组不良反应发生率低于比对组,但差异无统计学意义(P>0.05)。结论对绝经后骨质疏松性椎体压缩骨折患者实施经皮椎体成形术联合利塞膦酸钠治疗有助于恢复椎体高度,及时纠正后凸畸形,避免再次骨折,不良反应发生率低。Objective To analyze the application effect of percutaneous vertebroplasty combined with risedronate so-dium in the treatment of postmenopausal osteoporotic vertebral compression fractures.Methods A total of 64 patients with postmenopausal osteoporotic vertebral compression fractures admitted to the Department of Spinal Trauma Sur-gery,Shouguang People's Hospital of Shandong Province from October 2020 to October 2021 were conveniently se-lected as the research objects.According to the different treatment methods,they were divided into comparison group and study group,with 32 cases in each group.The comparison group was treated with conservative treatment,and the study group was treated with percutaneous vertebroplasty combined with risedronate sodium.The total effective rate of treatment,kyphotic Cobb angle,vertebral height compression rate at different treatment time and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group 93.75%(30/32)was higher than 81.25%(26/32)in the comparison group,but the difference was not statistically significant(χ^(2)=1.286,P=0.257).At 15 days and 6 months after treatment,the Cobb angle of kyphosis in the study group was smaller than that in the control group,and the differences were statistically significant(both P<0.05).At 15 days and 6 months af-ter treatment,the vertebral height compression rate of the study group was lower than that of the comparison group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in the study group was lower than that in the comparison group,but the difference was not statistically significant(P>0.05).Conclusion Percutaneous vertebroplasty combined with risedronate sodium in the treatment of postmenopausal osteoporotic verte-bral compression fractures is helpful to restore vertebral height,correct kyphosis in time,avoid re-fracture and the in-cidence of adverse reactions is lower.

关 键 词：经皮椎体成形术 利塞膦酸钠 绝经 骨质疏松性椎体压缩骨折 

分 类 号：R68[医药卫生—骨科学]