滑膜巨噬细胞在类风湿关节炎中的研究进展  

Research Progress of Synovial Macrophages in Rheumatoid Arthritis

作　　者：庞春艳[1] 白力[1] PANG Chunyan;BAI Li(Central Laboratory/Inner Mongolia Key Laboratory of Autoimmunity,the First Affiliated Hospital of Baotou Medical College,Baotou 014010,China)

机构地区：[1]包头医学院第一附属医院中心实验室、内蒙古自治区自体免疫学重点实验室,内蒙古包头014010

出　　处：《医学综述》2024年第20期2477-2481,共5页Medical Recapitulate

基　　金：内蒙古自治区自然科学基金项目(2023MS08065)。

摘　　要：类风湿关节炎(RA)是以侵蚀性、对称性多关节炎为主要临床表现的自身免疫性疾病,基本病理改变为滑膜炎和血管翳形成。在RA患者的滑膜组织中有多种免疫细胞浸润,包括巨噬细胞、T淋巴细胞和B淋巴细胞等。滑膜巨噬细胞(SMs)在RA的发生和发展中起至关重要的作用。目前SMs主要有两种来源,一种来源于外周血单核细胞浸润到滑膜组织的巨噬细胞,另一种是滑膜组织驻留巨噬细胞。由于SMs的异质性,其在RA的发生和发展中起不同作用,SMs可以加速RA的疾病进展,但具有不同细胞表面标志物的SMs亚群也可以形成保护屏障,延缓RA的发生和发展。因此,未来应深入探讨SMs的来源及不同细胞表面标志物的SMs在RA疾病进展中的作用机制,以为RA的治疗提供依据。Rheumatoid arthritis(RA)is an autoimmune disease with bone erosion and symmetrical polyarthritis as the main clinical manifestations,and the basic pathological changes are the formation of synovitis and pannus.There are various immune cell infiltrates in the synovial tissue of RA patients,including macrophages,T lymphocytes,and B lymphocytes.Synovial macrophages(SMs)play a crucial role in the occurrence and development of RA.At present,there are two main sources of SMs:macrophages infiltrated into synovial tissue by peripheral blood mononuclear cells,and macrophages residing in synovial tissue.Due to the heterogeneity of SMs,they play different roles in the occurrence and development of RA.SMs can accelerate the disease progression of RA,but subgroups of SMs with different cell surface markers can also form protective barriers,delaying the occurrence and development of RA.Therefore,in the future,the sources of SMs and the mechanisms of action of SMs with different cell surface markers in the progression of RA disease should be further explored,in order to provide a basis for the treatment of RA.

关 键 词：类风湿关节炎 滑膜巨噬细胞 异质性 细胞表面标志物 

分 类 号：R593.22[医药卫生—内科学]