醒脑静注射液联合注射用乙酰谷酰胺对重型颅脑损伤患者炎症反应的影响分析  

Analysis of the effect of Xingnaojing injection combined with acetylglutamide for injection on inflammatory response in patients with severe craniocerebral injury

作　　者：梁伟 LIANG Wei(Pharmacy Intravenous Admixture Services,Feicheng Hospital of Shandong Yiyang Health Group,Feicheng 271608,China)

机构地区：[1]山东颐养健康集团肥城医院静配中心,271608

出　　处：《中国现代药物应用》2024年第17期13-16,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 研究醒脑静注射液联合注射用乙酰谷酰胺对重型颅脑损伤患者炎症反应的影响。方法 将200例重型颅脑损伤患者作为研究对象,随机分为观察组及对照组,每组100例。对照组患者采用注射用乙酰谷酰胺单一治疗,观察组患者采用醒脑静注射液联合注射用乙酰谷酰胺治疗。对比两组患者治疗效果、美国国立卫生研究院卒中量表(NIHSS)评分、不良反应发生率及炎症指标。结果 观察组患者治疗前NIHSS评分和对照组对比,无差异(P>0.05);观察组治疗后的NIHSS评分(11.02±1.52)分和对照组的(20.52±1.71)分对比,存在差异(P<0.05)。观察组患者总有效率96.00%和对照组的79.00%对比,存在差异(P<0.05)。观察组患者不良反应发生率3.00%低于对照组的10.00%,存在差异(P<0.05)。两组患者治疗前肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平对比,无差异(P>0.05);治疗后,两组TNF-α、IL-6、CRP均低于治疗前,且观察组患者TNF-α、IL-6、CRP水平分别为(22.11±1.66)ng/L、(9.17±1.24)pg/ml、(4.01±1.24)mg/L,均低于对照组的(24.16±1.02)ng/L、(15.99±1.04)pg/ml、(7.77±1.98)mg/L,存在差异(P<0.05)。结论 对重型颅脑损伤患者开展醒脑静注射液联合注射用乙酰谷酰胺治疗后取得显著的治疗效果,能有效减轻患者炎症反应。Objective To study the effect of Xingnaojing injection combined with acetylglutamide for injection on inflammatory response in patients with severe craniocerebral injury.Methods 200 patients with severe traumatic brain injury were selected as the study subjects.The patients were randomly divided into an observation group and a control group,with 100 patients in each group.The control group received acetylglutamide for injection,while the observation group received Xingnaojing injection combined with acetylglutamide for injection.The therapeutic effect,National Institutes of Health Stroke Scale(NIHSS) score,incidence of adverse reactions and inflammatory indicators were compared between the two groups.Results There was no difference in NIHSS score between the observation group and the control group before treatment(P>0.05).After treatment,NIHSS score of(11.02±1.52) points in the observation group was different from(20.52±1.71) points in the control group(P<0.05).The total effective rate of 96.00% in the observation group was different from 79.00% in the control group(P<0.05).The incidence of adverse reactions of 3.00% in the observation group was lower than 10.00% in the control group(P<0.05).Before treatment,there was no difference in the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and C-reactive protein(CRP) between the two groups(P>0.05).After treatment,the levels of TNF-α,IL-6 and CRP in both groups were lower than those before treatment;the levels of TNF-α,IL-6 and CRP in the observation group were(22.11±1.66) ng/L,(9.17±1.24) pg/ml and(4.01±1.24) mg/L,which were lower than(24.16±1.02) ng/L,(15.99±1.04) pg/ml and(7.77±1.98) mg/L in the control group(P<0.05).Conclusion Combination therapy of Xingnaojing injection and acetylglutamide for injection for patients with severe traumatic brain injury has achieved significant therapeutic effects and can effectively alleviate the patient's inflammatory response.

关 键 词：醒脑静注射液 注射用乙酰谷酰胺 重型颅脑损伤 

分 类 号：R651.15[医药卫生—外科学]