盆底仿生物电刺激辅助激素治疗薄型子宫内膜不孕症对患者子宫内膜容受性和妊娠结局的影响  

Effects of the pelvic floor biomimetic electrical stimulation therapy for patients with thin endometrium infertility on their endometrial receptivity and pregnancy outcomes

作　　者：陈洪 郑琴仙 林洁君 管珊 CHEN Hong;ZHENG Qinxian;LIN Jiejun;GUAN Shan(Sanmen County People's Hospital,Sanmen,Zhejiang Province,317100)

机构地区：[1]浙江省三门县人民医院,317100

出　　处：《中国计划生育学杂志》2024年第9期2020-2024,共5页Chinese Journal of Family Planning

摘　　要：目的:观察盆底仿生物电刺激辅助治疗薄型子宫内膜不孕症对患者子宫内膜容受性和妊娠结局的影响。方法:将将2021年1月-2023年12月本院就诊80例薄型子宫内膜不孕症患者随机分为观察组(n=40,常规激素治疗+盆底仿生物电刺激治疗)与对照组(n=40,常规激素治疗),两组均以1个月经周期为1个疗程,共治疗3个疗程。比较治疗前及治疗3个疗程后两组子宫内膜情况(子宫内膜类型、子宫内膜厚度、子宫内膜容积),子宫动脉血流动力学参数(搏动指数、阻力指数、血流速度峰谷比)及性激素水平,统计两组治疗结束后1年内妊娠情况。结果:治疗3个疗程后,观察组A型子宫内膜占比(67.5%)、子宫内膜厚度(9.48±0.65mm)、子宫内膜容积(2.34±0.38 cm^(2))以及血清雌二醇、孕酮水平均高于对照组(32.0%、8.23±0.79mm、1.71±0.36 cm^(2)),子宫动脉血流动力学参数、血清黄体生成素、睾酮、卵泡刺激素、泌乳素水平均低于对照组;治疗后1年内,妊娠率观察组(42.5%)高于对照组(20.0%)(均P<0.05)。结论:盆底仿生物电刺激辅助激素治疗,可有效提高薄型子宫内膜不孕症患者子宫内膜容受性,改善患者血流动力学和性激素水平,对提高妊娠率有积极作用。Objective:To observe the effects of pelvic floor biomimetic electrical stimulation therapy for patients with thin endometrium infertility on their endometrial receptivity and pregnancy outcomes.Methods:8 patients with mesosterenotic endometrial infertility were randomly divided into observation group(40 cases given conventional hormone therapy combined with pelvic floor biomimetic electrical stimulation)and control group(40 cases given conventional hormone therapy).The patients in both groups were treated for 3 courses of treatment(1 menstrual cycle as 1 course).The endometrial status,such as the endometrium type,the endometrial thickness(EMT)and the endometrial volume,the values of uterine artery hemodynamic parameters,such as pulsatility index(PI),resistance index(RI)and peak systolic velocity/end diastolic velocity(S/D),and the levels of sex hormones of the patients before treatment and after 3 courses of treatment were compared between the two groups.The pregnancy status of the patients in the two groups within 1 year after the end of treatment was statistically analyzed.Results:After 3 courses of treatments,the proportion(67.5%)of type A endometrium,the EMT(9.48±0.65mm)and the endometrial volume(2.34±0.38 cm^(2))of the patients in the observation group were significantly higher than those(32.0%,8.23±0.79mm and 1.71±0.36 cm^(2))of the patients in the control group,and the levels of serum estradiol(E_(2))and progesterone(P)of the patients in the observation group were significantly higher than those of the patients in the control group,while the values of uterine artery hemodynamic parameters and the levels of the luteinizing hormone(LH),testosterone(T),follicle-stimulating hormone(FSH)and prolactin(PRL)of the patients in the observation group were significantly lower than those of the patients in the control group.The pregnancy rate(42.5%)of the patients in the observation group was significantly higher than that(20.0%)of the patients in the control group(all P<0.05).Conclusion:Pelvic floor biomimetic ele

关 键 词：不孕症 薄型子宫内膜 仿生物电刺激 子宫内膜容受性 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]