大柴胡汤加味治疗结直肠癌术后患者胃肠功能障碍效果及对血清生长抑素、血管活性肠肽水平的影响研究  

Research on the therapeutic efficacy of modified Dachaihu decoction on gastrointestinal dysfunction in patients with colorectal cancer after surgery and its impact on levels of serum somatostatin and vasoactive intestinal peptide

作　　者：杨先炜 肖佑[2] 尹晖明 YANG Xianwei;XIAO You;YIN Huiming(Center of Minimally Invasive Surgery,Department of General Surgery,the Second Hospital of Hunan University of Chinese Medicine,Hunan,Changsha 410005,China;DepartmentⅥof Anorectum,the Second Hospital of Hunan University of Chinese Medicine,Hunan,Changsha 410005,China)

机构地区：[1]湖南中医药大学第二附属医院普通外科微创中心,湖南长沙410005 [2]湖南中医药大学第二附属医院肛肠六科,湖南长沙410005

出　　处：《中国医药科学》2024年第17期118-121,共4页China Medicine And Pharmacy

基　　金：湖南省自然科学基金项目(2021JJ40413);湖南中医药大学中医学一流学科开放基金立项计划(2021ZYX18);湖南省中医药科研课题(B2023095)。

摘　　要：目的探讨大柴胡汤加味治疗结直肠癌术后患者胃肠功能障碍效果及对血清血管活性肠肽(VIP)、生长抑素(SS)水平的影响。方法选取2021年10月至2022年10月湖南中医药大学第二附属医院收治的80例结直肠癌术后发生胃肠功能障碍的患者作为研究对象,采用随机数表法分为对照组(n=40,行常规对症治疗)和观察组(n=40,行常规对症+大柴胡汤加味治疗)。比较两组胃肠道功能恢复情况、血清指标、中医证候积分及生活质量。结果观察组首次排气及排便时间、肠鸣音恢复时间短于对照组,差异有统计学意义(P<0.05)。与治疗前比较,两组治疗5 d后VIP、SS水平均有降低,胃动素(MTL)水平均有升高,差异有统计学意义(P<0.05);治疗5 d后,观察组VIP、SS水平低于对照组,MTL水平高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,两组治疗5 d后中医证候积分均有降低,卡氏生存质量量表(KPS)评分均有升高,差异有统计学意义(P<0.05);治疗5 d后,观察组中医证候积分低于对照组,KPS评分高于对照组,差异有统计学意义(P<0.05)。结论在结直肠癌术后胃肠功能障碍患者中应用大柴胡汤加味治疗,其效果明显,可有效改善患者中医症状,促进患者胃肠功能恢复,改善患者生活质量。Objective To investigate the therapeutic efficacy of modified Dachaihu decoction on gastrointestinal dysfunction in patients with colorectal cancer after surgery and its impact on serum levels of vasoactive intestinal peptide(VIP)and somatostatin(SS).Methods A total of 80 patients who developed gastrointestinal dysfunction after colorectal cancer surgery admitted to and treated in the Second Hospital of Hunan University of Chinese Medicine from October 2021 to October 2022 were selected as the research object,and they were divided into the control group(n=40,treated with conventional symptomatic therapy)and the observation group(n=40,treated with conventional symptomatic therapy combined with modified Dachaihu decoction)by random number table method.The recovery situation of gastrointestinal function,serum indices,traditional Chinese medicine syndrome scores and quality of life were compared between the two groups.Results The recovery time of the first exhaust,defecation and bowel sounds in the observation group was shorter than that in the control group,with statistically significant differences(P<0.05).Compared with those before treatment,5 days after therapy,the levels of VIP and SS in both groups decreased to a certain extent, and the levels of motilin (MTL) all increased to a certain extent, with statistically significant differences (P < 0.05). 5 days after treatment, the levels of VIP and SS in the observation group were lower than those in the control group, and the level of MTL was higher than that in the control group, with statistically significant differences (P < 0.05). Compared with those before treatment, 5 days after treatment, the scores of traditional Chinese medicine syndromes in both groups decreased, and the scores of Karnofsky performance status (KPS) all increased, with statistically significant differences (P < 0.05). 5 days after treatment, the traditional Chinese medicine syndrome score of the observation group was lower than that of the control group, and the KPS score was higher than t

关 键 词：结直肠癌 大柴胡汤加味 胃肠功能障碍 生长抑素 血管活性肠肽 

分 类 号：R273[医药卫生—中西医结合]