中药润肺膏剂联合噻托溴铵治疗慢性阻塞性肺疾病稳定期的临床对照研究  

Clinical controlled study on the combination of traditional Chinese medicine moisturizing lung ointment and tiotropium bromide in the treatment of stable chronic obstructive pulmonary disease

作　　者：姚灵锡 刘涛 高炳栋 张慧娟 张波 YAO Lingxi;LIU Tao;GAO Bingdong;ZHANG Huijuan;ZHANG Bo(Intensive Care Medicine Department,Gaomi People’s Hospital Affiliated to Shandong Second Medical University,Shandong,Gaomi 261500,China)

机构地区：[1]山东第二医科大学附属高密市人民医院重症医学科,山东高密261500

出　　处：《中国医药科学》2024年第17期130-133,共4页China Medicine And Pharmacy

基　　金：山东省潍坊市科学技术发展计划项目(2022YX133)。

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)稳定期的中西医治疗效果和抗炎机制,评价治疗对患者生活质量的影响。方法选取2021年11月至2023年1月山东第二医科大学附属高密市人民医院收治的140例Ⅱ级COPD稳定期患者作为研究对象,根据随机数表法分为研究组与对照组,每组各70例。全部使用西医基础疗法,给予噻托溴铵粉吸入剂每日1次,每次18μg。研究组加用中药润肺膏剂每日2次,每次20 g。两组治疗均以2个月为1个疗程,连续治疗2个疗程。检测治疗前后两组患者肺功能以及肿瘤坏死因子-α、白细胞介素-6、白细胞介素-8血清炎性因子水平,以COPD测试量表考察患者生活质量,并记录患者病情改变、住院情况。结果治疗后,研究组COPD测试量表评分低于对照组,差异有统计学意义(P<0.05);研究组肺功能指标优于对照组,差异有统计学意义(P<0.05);研究组血清炎性因子水平低于对照组,差异有统计学意义(P<0.05);研究组感冒次数、急性加重次数、住院次数低于对照组,差异有统计学意义(P<0.05)。结论中西医治疗能有效改善Ⅱ级COPD稳定期患者的临床症状,提高患者生活质量,降低炎性因子水平,减少急性发作、感冒和住院次数,效果明显。Objective To explore the therapeutic effects and anti-inflammatory mechanisms of traditional Chinese and Western medicine in the patients with stable chronic obstructive pulmonary disease(COPD),and evaluate the impact of treatment on the quality of life of patients.Methods A total of 140 patients with stable COPD of GradeⅡin Gaomi People’s Hospital Affiliated to Shandong Second Medical University from November 2021 to January 2023 were selected as the study subject,and were randomly divided into study group and control group according to a random number table,with 70 patients in each group.All patients were treated with basic western medicine and given a daily dose of 18μg of tiotropium bromide powder inhaler.The study group added traditional Chinese medicine to moisten lung ointment twice a day,20 g each time.Both groups were treated for 2 months as 1 course of treatment and 2 consecutive courses of treatment.Lung function and serum inflammatory factor levels of tumor necrosis factor-α,interleukin-6 and interleukin-8 were measured before and after treatment,the quality of life was examined by the COPD test scale,and changes in patients’conditions and hospitalization were recorded.Results After treatment,the COPD assessment test scale score of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The lung function indexes of the study group were better than that of the control group,and the difference was statistically significant(P<0.05).The serum inflammatory factor level of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The number of colds,the number of acute exacerbations,and the number of hospitalizations of the study groups were lower than that of the control group,the difference is statistically significant (P < 0.05). Conclusion Chinese and Western medicine treatment can effectively improve clinical symptoms in the stable stage of class Ⅱ COPD, improve patients’quality

关 键 词：慢性阻塞性肺疾病 炎性因子 肿瘤坏死因子 白细胞介素 中药膏剂 

分 类 号：R563.9[医药卫生—呼吸系统]